NP-202 | CAS#6068-78-6 | post-MI remodeling inhibitor

MedKoo Cat#: 561480 | Name: NP-202

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NP-202 is an experimental drug for potential use as a treatment for left ventricular systolic dysfunction. NP-202 works in a different way to the drugs that are currently approved, and has been shown in animal studies to prevent post-MI remodeling.

Chemical Structure

NP-202

CAS#6068-78-6

Theoretical Analysis

MedKoo Cat#: 561480

Name: NP-202

CAS#: 6068-78-6

Chemical Formula: C15H10O5

Exact Mass: 270.0528

Molecular Weight: 270.24

Elemental Analysis: C, 66.67; H, 3.73; O, 29.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NP-202; NP 202; NP202; 3,3',4'-Trihydroxyflavone; 3',4'-Dihydroxyflavonol; 5,7-Dideoxyquercetin;

IUPAC/Chemical Name

3',4'-dihydroxyflavonol

InChi Key

KPGMHZQXQVDYNT-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H10O5/c16-10-6-5-8(7-11(10)17)15-14(19)13(18)9-3-1-2-4-12(9)20-15/h1-7,16-17,19H

SMILES Code

O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=C1C=CC=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 270.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Thomas CJ, Lim NR, Kedikaetswe A, Yeap YY, Woodman OL, Ng DC, May CN. Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3',4'-dihydroxyflavonol. Eur J Pharmacol. 2015 Jul 5;758:53-9. doi: 10.1016/j.ejphar.2015.03.054. Epub 2015 Mar 25. PubMed PMID: 25820159. 2: Lim NR, Thomas CJ, Silva LS, Yeap YY, Yap S, Bell JR, Delbridge LM, Bogoyevitch MA, Woodman OL, Williams SJ, May CN, Ng DC. Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38(MAPK) signalling involves CaMKII inhibition. Biochem J. 2013 Dec 1;456(2):149-61. doi: 10.1042/BJ20121538. PubMed PMID: 24032640. 3: Thomas CJ, Ng DC, Patsikatheodorou N, Limengka Y, Lee MW, Darby IA, Woodman OL, May CN. Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK. Eur J Pharmacol. 2011 May 11;658(2-3):160-7. doi: 10.1016/j.ejphar.2011.02.041. Epub 2011 Mar 1. PubMed PMID: 21371449.