NF-1819 is a potent and selective irreversible monoacylglycerol lipase (MAGL) inhibitor with IC₅₀ values of 0.25 nM for rat MAGL and 7.4 nM for human MAGL. It exhibits 389-fold selectivity over human fatty acid amide hydrolase (FAAH) and shows minimal binding to cannabinoid receptors (IC₅₀ > 10 µM). NF-1819 demonstrates in vivo efficacy by alleviating symptoms in a multiple sclerosis model and exhibiting analgesic effects in an acute inflammatory pain model. It also reduces neuropathic hypersensitivity induced by oxaliplatin.
MedKoo Cat#: 530933
Name: NF-1819
CAS#: 1881244-28-5
Chemical Formula: C24H22FN5O4
Exact Mass: 463.1656
Molecular Weight: 463.47
Elemental Analysis: C, 62.20; H, 4.78; F, 4.10; N, 15.11; O, 13.81
The following data is based on the product molecular weight 463.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
