MedKoo Cat#: 407821 | Name: GSK-2250665A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK-2250665A is a Itk inhibitor (pKi = 9.2).

Chemical Structure

GSK-2250665A
GSK-2250665A
CAS#1246030-96-5

Theoretical Analysis

MedKoo Cat#: 407821

Name: GSK-2250665A

CAS#: 1246030-96-5

Chemical Formula: C26H29N5OS

Exact Mass: 459.2093

Molecular Weight: 459.61

Elemental Analysis: C, 67.95; H, 6.36; N, 15.24; O, 3.48; S, 6.98

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
GSK-2250665A; GSK 2250665A; GSK2250665A; GSK-2250665; GSK 2250665; GSK2250665.
IUPAC/Chemical Name
trans-4-[[4-[(6-Ethyl-2-benzothiazolyl)amino]-6-(phenylmethyl)-2-pyrimidinyl]amino]cyclohexanol
InChi Key
DPRNXTSMYVCYLJ-XUTJKUGGSA-N
InChi Code
InChI=1S/C26H29N5OS/c1-2-17-8-13-22-23(15-17)33-26(29-22)31-24-16-20(14-18-6-4-3-5-7-18)28-25(30-24)27-19-9-11-21(32)12-10-19/h3-8,13,15-16,19,21,32H,2,9-12,14H2,1H3,(H2,27,28,29,30,31)/t19-,21-
SMILES Code
O[C@H]1CC[C@H](NC2=NC(CC3=CC=CC=C3)=CC(NC4=NC5=CC=C(CC)C=C5S4)=N2)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 459.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Alder et al (2013) Identification of a novel and selective series of Itk inhibitors via a template-hopping strategy. ACS Med.Chem.Lett. 12 948 PMID: 24900590