Oe-9000 | CAS#675132-92-0 | Anaesthetic

MedKoo Cat#: 561471 | Name: Oe-9000

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oe-9000 is a novel blocker of voltage-gated Na(+) currents in neurons. It reversibly reduces slowly activating and inactivating tetrodotoxin-resistant (TTX-R) Na(+) currents as well as rapidly activating and inactivating TTX-sensitive (TTX-S) Na(+) currents at low micromolar concentrations. Oe-9000 is a highly potent local anaesthetic related to fomocaine.

Chemical Structure

Oe-9000

CAS#675132-92-0

Theoretical Analysis

MedKoo Cat#: 561471

Name: Oe-9000

CAS#: 675132-92-0

Chemical Formula: C21H29NO3

Exact Mass: 343.2147

Molecular Weight: 343.47

Elemental Analysis: C, 73.44; H, 8.51; N, 4.08; O, 13.97

Price and Availability

Size	Price	Availability	Quantity
5g	USD 6,350.00
25g	USD 22,550.00

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Related CAS #

No Data

Synonym

Oe-9000; Oe 9000; Oe9000;

IUPAC/Chemical Name

2,2'-((4-(4-(phenoxymethyl)phenyl)butyl)azanediyl)bis(ethan-1-ol)

InChi Key

WRYVVYWBQAWWQN-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H29NO3/c23-16-14-22(15-17-24)13-5-4-6-19-9-11-20(12-10-19)18-25-21-7-2-1-3-8-21/h1-3,7-12,23-24H,4-6,13-18H2

SMILES Code

OCCN(CCO)CCCCC1=CC=C(COC2=CC=CC=C2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Oe-9000 is a novel blocker of voltage-gated Na(+) currents in neurons.

In vitro activity:

TBD

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 343.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Baumgart M, Feller C, Natura G, Dahse T, Schaible HG, Dahse I. Blockade of TTX-resistant and TTX-sensitive Na+ currents in cultured dorsal root ganglion neurons by fomocaine and the fomocaine derivative Oe 9000. Brain Res. 2010 Oct 28;1358:54-63. doi: 10.1016/j.brainres.2010.08.033. Epub 2010 Aug 19. PubMed PMID: 20727863. 2: Dahse T, Wennek-Klose J, Listing M, Fleck C, Oelschläger H. [In vitro investigations of phase I metabolism of the fomocaine derivative Oe 9000 with pig liver homogenates]. Pharmazie. 2006 Nov;61(11):943-51. German. PubMed PMID: 17152988. 3: Fleck C, Wennek-Klose J, Wange J, Oelschläger H. Effects and toxicity of new fomocaine derivatives and of 2-hydroxypropyl-beta-cyclodextrin inclusion compounds in rats. Arzneimittelforschung. 2004;54(5):265-74. PubMed PMID: 15212188. 4: Fleck C, Karge E, Loy S, Wennek-Klose J, Listing M, Oelschläger H. Local anaesthetic effects and toxicity of seven new diethanolamine and morpholine derivatives of fomocaine. Testing in rats compared with procaine and tetracaine. Arzneimittelforschung. 2003;53(3):221-8. PubMed PMID: 12705179.