MedKoo Cat#: 561450 | Name: TOP1210

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TOP1210 a narrow spectrum kinase inhibitor. TOP1210 potently inhibits P38α, Src, and Syk kinase activities.

Chemical Structure

TOP1210
CAS#1628439-59-7

Theoretical Analysis

MedKoo Cat#: 561450

Name: TOP1210

CAS#: 1628439-59-7

Chemical Formula: C45H48N8O6

Exact Mass: 796.3697

Molecular Weight: 796.93

Elemental Analysis: C, 67.82; H, 6.07; N, 14.06; O, 12.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TOP1210; TOP-1210; TOP 1210;
IUPAC/Chemical Name
3-((4-((4-(3-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-ethynyl-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)benzamide
InChi Key
MMBUUNLZGRAVKE-UHFFFAOYSA-N
InChi Code
InChI=1S/C45H48N8O6/c1-7-31-26-32(42(54)46-20-21-57-24-25-58-23-22-56-6)28-33(27-31)48-43-47-19-18-41(51-43)59-38-17-16-37(35-10-8-9-11-36(35)38)49-44(55)50-40-29-39(45(3,4)5)52-53(40)34-14-12-30(2)13-15-34/h1,8-19,26-29H,20-25H2,2-6H3,(H,46,54)(H,47,48,51)(H2,49,50,55)
SMILES Code
O=C(NCCOCCOCCOC)C1=CC(C#C)=CC(NC2=NC=CC(OC3=C4C=CC=CC4=C(NC(NC5=CC(C(C)(C)C)=NN5C6=CC=C(C)C=C6)=O)C=C3)=N2)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 796.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Biancheri P, Foster MR, Fyfe MC, MacDonald TT, Sirohi S, Solanke Y, Wood E, Rowley A, Webber S, Walshe CA. Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal Proinflammatory Immune Response in Ulcerative Colitis. Inflamm Bowel Dis. 2016 Jun;22(6):1306-15. doi: 10.1097/MIB.0000000000000759. PubMed PMID: 27104822; PubMed Central PMCID: PMC4869561.