MedKoo Cat#: 530923 | Name: VU6005649
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU6005649 is a potent and CNS Penetrant mGlu7/8 Receptor PAM with in vivo efficacy in a mouse contextual fear conditioning model.

Chemical Structure

VU6005649
VU6005649
CAS#2137047-43-7

Theoretical Analysis

MedKoo Cat#: 530923

Name: VU6005649

CAS#: 2137047-43-7

Chemical Formula: C16H12F5N3O

Exact Mass: 357.0901

Molecular Weight: 357.28

Elemental Analysis: C, 53.79; H, 3.39; F, 26.59; N, 11.76; O, 4.48

Price and Availability

Size Price Availability Quantity
10mg USD 500.00
50mg USD 1,150.00
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Related CAS #
No Data
Synonym
VU6005649; VU-6005649; VU 6005649
IUPAC/Chemical Name
3-(2,3-Difluoro-4-methoxy-phenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
InChi Key
NYBZCKAQIIPSDS-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3
SMILES Code
FC(C1=CC(C)=NC2=C(C3=CC=C(OC)C(F)=C3F)C(C)=NN12)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Abe et al (2017) Discovery of VU6005649, a CNS penetrant mGlu7/8 receptor PAM derived from a series of pyrazolo[1,5-a]pyrimidines. ACS.Med.Chem.Lett. 8 1110 PMID: 29057060 Lei X, Hofmann CS, Rodriguez AL, Niswender CM. Differential Activity of Orthosteric Agonists and Allosteric Modulators at Metabotropic Glutamate Receptor 7. Mol Pharmacol. 2023 Jul;104(1):17-27. doi: 10.1124/molpharm.123.000678. Epub 2023 Apr 27. PMID: 37105671; PMCID: PMC10289241.