KUNG94 is a potent and selective Grp94 inhibitor (IC50 = 8 nM). KUNG94 manifests Grp94-selective inhibition in cells and represents a new scaffold for the development of Grp94-selective inhibitors.Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the 90 kDa heat shock protein (Hsp90) family and represents a promising therapeutic target for the treatment of several diseases.
MedKoo Cat#: 530910
Name: KUNG94
CAS#: 2134571-29-0
Chemical Formula: C22H18FNO3
Exact Mass: 363.1271
Molecular Weight: 363.39
Elemental Analysis: C, 72.72; H, 4.99; F, 5.23; N, 3.85; O, 13.21
The following data is based on the product molecular weight 363.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |