MedKoo Cat#: 530910 | Name: KUNG94

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KUNG94 is a potent and selective Grp94 inhibitor (IC50 = 8 nM). KUNG94 manifests Grp94-selective inhibition in cells and represents a new scaffold for the development of Grp94-selective inhibitors.Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the 90 kDa heat shock protein (Hsp90) family and represents a promising therapeutic target for the treatment of several diseases.

Chemical Structure

KUNG94
KUNG94
CAS#2134571-29-0

Theoretical Analysis

MedKoo Cat#: 530910

Name: KUNG94

CAS#: 2134571-29-0

Chemical Formula: C22H18FNO3

Exact Mass: 363.1271

Molecular Weight: 363.39

Elemental Analysis: C, 72.72; H, 4.99; F, 5.23; N, 3.85; O, 13.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KUNG94; KUNG-94; KUNG 94.
IUPAC/Chemical Name
(5-(4-fluorobenzyl)-2,4-dihydroxyphenyl)(isoindolin-2-yl)methanone
InChi Key
SDHXQALTNKXTMI-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H18FNO3/c23-18-7-5-14(6-8-18)9-17-10-19(21(26)11-20(17)25)22(27)24-12-15-3-1-2-4-16(15)13-24/h1-8,10-11,25-26H,9,12-13H2
SMILES Code
FC1=CC=C(CC2=C(O)C=C(O)C(C(N3CC(C=CC=C4)=C4C3)=O)=C2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 363.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Resorcinol-Based Grp94-Selective Inhibitors Anuj Khandelwal,†,∥,§ Vincent M. Crowley,†,§ and Brian S. J. Blagg*,‡ †Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott Hall 4070, Lawrence, Kansas 66045, United States ‡Warren Family Research Center for Drug Discovery and Development and Department of Chemistry & Biochemistry, University of Notre Dame, 305 McCourtney Hall, Notre Dame, Indiana 46556, United States