Synonym
Alazopeptin; AA223 Lederle; AA 223 Lederle; AA-223 Lederle
IUPAC/Chemical Name
Allyl-(6-diazo-5-oxo)-norleucyl-(6-diazo-5-oxo)-norleucine
InChi Key
LKVFXQOHKMMISY-STQMWFEESA-N
InChi Code
InChI=1S/C15H20N6O5/c1-2-7-21(13(15(25)26)6-4-11(23)9-20-18)14(24)12(16)5-3-10(22)8-19-17/h2,8-9,12-13H,1,3-7,16H2,(H,25,26)/t12-,13-/m0/s1
SMILES Code
O=C(O)[C@H](CCC(C=[N+]=[N-])=O)N(CC=C)C([C@H](CCC(C=[N+]=[N-])=O)N)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
364.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Patterson EL, Johnson BL, DeVoe SE, Bohonos N. Structure of the antitumor antibiotic alazopeptin. Antimicrob Agents Chemother (Bethesda). 1965;5:115-8. PubMed PMID: 5883414.
2: DE VOE SE, RIGLER NE, SHAY AJ, MARTIN JH, BOYD TC, BACKUS EJ, MOWAT JH, BOHONOS N. Alazopeptin; production, isolation, and chemical characteristics. Antibiot Annu. 1956-1957:730-5. PubMed PMID: 13425456.
3: Ishiyama A, Otoguro K, Namatame M, Nishihara A, Furusawa T, Masuma R, Shiomi K, Takahashi Y, Ichimura M, Yamada H, Omura S. In vitro and in vivo antitrypanosomal activitiy of two microbial metabolites, KS-505a and alazopeptin. J Antibiot (Tokyo). 2008 Oct;61(10):627-32. doi: 10.1038/ja.2008.83. PubMed PMID: 19168977.
4: THIERSCH JB. Effect of alazopeptin on litter and fetus of the rat in utero. Proc Soc Exp Biol Med. 1958 Apr;97(4):888-9. PubMed PMID: 13554513.
5: Hata T, Umezawa I, Iwai Y, Katagiri M, Awaya J. Studies on the antitumor activity of an alazopeptin isolated from a new strain of Streptomyces. J Antibiot (Tokyo). 1973 Mar;26(3):181-3. PubMed PMID: 4205875.
