JNJ-DGAT2-A | CAS#1962931-71-0 | DGAT2-selective inhibitor

MedKoo Cat#: 561396 | Name: JNJ-DGAT2-A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JNJ-DGAT2-A is a DGAT2-selective inhibitor. Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis. JNJ-DGAT2-A dose-dependently inhibited the generation of the three major TG species in HepG2 cells.

Chemical Structure

JNJ-DGAT2-A

CAS#1962931-71-0

Theoretical Analysis

MedKoo Cat#: 561396

Name: JNJ-DGAT2-A

CAS#: 1962931-71-0

Chemical Formula: C24H16BrFN4O2S

Exact Mass: 522.0161

Molecular Weight: 523.38

Elemental Analysis: C, 55.08; H, 3.08; Br, 15.27; F, 3.63; N, 10.71; O, 6.11; S, 6.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

JNJ-DGAT2-A; JNJDGAT2A; JNJ DGAT2 A;

IUPAC/Chemical Name

3-Bromo-4-[2-fluoro-4-({4-oxo-2-[(2-pyridin-2-ylethyl)amino]1,3-thiazol-5(4H)-ylidene}methyl)phenoxy]benzonitrile

InChi Key

ZFRHAMOJHTZHLT-XKZIYDEJSA-N

InChi Code

InChI=1S/C24H16BrFN4O2S/c25-18-11-16(14-27)5-6-20(18)32-21-7-4-15(12-19(21)26)13-22-23(31)30-24(33-22)29-10-8-17-3-1-2-9-28-17/h1-7,9,11-13H,8,10H2,(H,29,30,31)/b22-13-

SMILES Code

N#CC1=CC=C(OC2=CC=C(/C=C(SC(NCCC3=NC=CC=C3)=N4)/C4=O)C=C2F)C(Br)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 523.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Qi J, Lang W, Geisler JG, et al. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. Journal of Lipid Research. 2012;53(6):1106-1116. doi:10.1194/jlr.M020156.