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MedKoo Cat#: 561383 | Name: Psoralidin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Psoralidin is a metabolic product from the seed of psoraleacorylifolia, possessing anti-inflammatory and immunomodulatory effects. Psoralidin inhibits lipopolysaccharide induced bone resorption by suppressing the inflammatory cytokines: TNF-α and IL-6 expression, as well as the ratio of RNAKL : OPG.

Chemical Structure

Psoralidin
Psoralidin
CAS#18642-23-4

Theoretical Analysis

MedKoo Cat#: 561383

Name: Psoralidin

CAS#: 18642-23-4

Chemical Formula: C20H16O5

Exact Mass: 336.0998

Molecular Weight: 336.34

Elemental Analysis: C, 71.42; H, 4.80; O, 23.78

Price and Availability

Size Price Availability Quantity
10mg USD 415.00
25mg USD 625.00
100mg USD 1,225.00
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Related CAS #
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Synonym
Psoralidin;
IUPAC/Chemical Name
3,9-Dihydroxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one
InChi Key
YABIJLLNNFURIJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H16O5/c1-10(2)3-4-11-7-14-17(9-15(11)22)25-20(23)18-13-6-5-12(21)8-16(13)24-19(14)18/h3,5-9,21-22H,4H2,1-2H3
SMILES Code
O=C1C2=C(OC3=C2C=CC(O)=C3)C4=C(O1)C=C(O)C(C/C=C(C)\C)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO and DMF
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Psoralidin induces cytotoxicity against various cancer cells. At 50 μM, psoralidin can induce the death of HeLa cancer cells through TNF-related apoptosis-inducing ligand-mediated events. Psoralidin can induce apoptosis of androgen-dependent (LNCaP, C4-2B) and androgen-independent (DU-145, PC-3) prostate cancer cells.
In vitro activity:
Psoralidin is a potent radical scavenger in physiological polar media.However, psoralidin is a moderate radical scavenger in lipid media. Psoralidin moderately reduces the basal ROS level in human keratinocytes at non-toxic concentrations, Reference: J Org Chem. 2023 May 5;88(9):5745-5751. https://pubmed.ncbi.nlm.nih.gov/37074959/
In vivo activity:
In a murine model of septic myocardial injury model, psoralidin improved cardiac function, attenuated inflammation, inhibited oxidative stress, improved mitochondrial function, regulated ERS, suppressed apoptosis, and increased NR1H3 and p-AMPK levels. Reference: Free Radic Biol Med. 2023 Aug 1;204:8-19. https://pubmed.ncbi.nlm.nih.gov/37085126/
Solvent mg/mL mM
Solubility
DMF 14.0 41.62
DMSO 14.0 41.62
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 336.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Boulebd H, Pereira DM. Examination of the Antioxidant Activity of Psoralidin: Computational Mechanistic Study and Impact on the ROS Level in Human Keratinocytes. J Org Chem. 2023 May 5;88(9):5745-5751. doi: 10.1021/acs.joc.3c00193. Epub 2023 Apr 19. PMID: 37074959. 2. Li S, Liu X, Nie Y, Yang L, Zhang C, Guo Y, Yang S, Li Z. Psoralidin Induced Differentiation from Adipose-derived Stem Cells to Nucleus Pulposus-like Cells by TGF-β/Smad Signaling. Curr Mol Med. 2023 May 30;23(7):688-697. doi: 10.2174/1566524022666220816165135. PMID: 35975860. 3. Yang Y, Lei W, Qian L, Zhang S, Yang W, Lu C, Song Y, Liang Z, Deng C, Chen Y, Tian Y, Zhao H. Activation of NR1H3 signaling pathways by psoralidin attenuates septic myocardial injury. Free Radic Biol Med. 2023 Aug 1;204:8-19. doi: 10.1016/j.freeradbiomed.2023.04.006. Epub 2023 Apr 20. PMID: 37085126. 4. Liang Z, Chen Y, Wang Z, Wu X, Deng C, Wang C, Yang W, Tian Y, Zhang S, Lu C, Yang Y. Protective effects and mechanisms of psoralidin against adriamycin-induced cardiotoxicity. J Adv Res. 2022 Sep;40:249-261. doi: 10.1016/j.jare.2021.12.007. Epub 2021 Dec 28. PMID: 36100330; PMCID: PMC9481943.
In vitro protocol:
1. Boulebd H, Pereira DM. Examination of the Antioxidant Activity of Psoralidin: Computational Mechanistic Study and Impact on the ROS Level in Human Keratinocytes. J Org Chem. 2023 May 5;88(9):5745-5751. doi: 10.1021/acs.joc.3c00193. Epub 2023 Apr 19. PMID: 37074959. 2. Li S, Liu X, Nie Y, Yang L, Zhang C, Guo Y, Yang S, Li Z. Psoralidin Induced Differentiation from Adipose-derived Stem Cells to Nucleus Pulposus-like Cells by TGF-β/Smad Signaling. Curr Mol Med. 2023 May 30;23(7):688-697. doi: 10.2174/1566524022666220816165135. PMID: 35975860.
In vivo protocol:
1. Yang Y, Lei W, Qian L, Zhang S, Yang W, Lu C, Song Y, Liang Z, Deng C, Chen Y, Tian Y, Zhao H. Activation of NR1H3 signaling pathways by psoralidin attenuates septic myocardial injury. Free Radic Biol Med. 2023 Aug 1;204:8-19. doi: 10.1016/j.freeradbiomed.2023.04.006. Epub 2023 Apr 20. PMID: 37085126. 2. Liang Z, Chen Y, Wang Z, Wu X, Deng C, Wang C, Yang W, Tian Y, Zhang S, Lu C, Yang Y. Protective effects and mechanisms of psoralidin against adriamycin-induced cardiotoxicity. J Adv Res. 2022 Sep;40:249-261. doi: 10.1016/j.jare.2021.12.007. Epub 2021 Dec 28. PMID: 36100330; PMCID: PMC9481943.
1: Wu Y, Feng K, Chen Y, Zhang H, Zhang M, Han B, Chen X, Yang L, Wang X, Li W, Tang J. Exploring the anti-inflammatory and immunomodulatory potential of licochalcone B against psoralidin-induced liver injury. J Ethnopharmacol. 2024 Jul 23;335:118600. doi: 10.1016/j.jep.2024.118600. Epub ahead of print. PMID: 39053714. 2: Li N, Liao S, Liu L, Wang X, Liang Z, Liu X, Song Y, Zhao S, Wu X, Tian Y, Xu X, Yang Y, Liu Q. Pleiotropic role of endoplasmic reticulum stress in the protection of psoralidin against sepsis-associated encephalopathy. Free Radic Biol Med. 2024 Aug 20;221:203-214. doi: 10.1016/j.freeradbiomed.2024.05.038. Epub 2024 May 22. PMID: 38788982. 3: Lee SE, Lee GH. Effects of psoralidin on the expression of glutamate decarboxylases and inhibitory synapse development. J Asian Nat Prod Res. 2024 Sep;26(9):1106-1114. doi: 10.1080/10286020.2024.2346297. Epub 2024 May 16. PMID: 38753588. 4: Ahmad F, Gupta A, Marzook H, Woodgett JR, Saleh MA, Qaisar R. Natural compound screening predicts novel GSK-3 isoform-specific inhibitors. Biochimie. 2024 May 7;225:68-80. doi: 10.1016/j.biochi.2024.05.002. Epub ahead of print. PMID: 38723940. 5: Shang H, Liu X, Pan J, Cheng H, Ma Z, Xiao C, Gao Y. Exploring the mechanism and phytochemicals in Psoraleae Fructus-induced hepatotoxicity based on RNA-seq, in vitro screening and molecular docking. Sci Rep. 2024 Jan 19;14(1):1696. doi: 10.1038/s41598-023-50454-0. PMID: 38242895; PMCID: PMC10799058. 6: Wang X, Liang Z, Liu Q, Ye X, Wu X, Deng C, Zhao L, Lu C, Qiu Z, Yao Y, Yang Y, Xu X. Identification of PIK3R5 as a hub in septic myocardial injury and the cardioprotective effects of Psoralidin. Phytomedicine. 2024 Jan;122:155146. doi: 10.1016/j.phymed.2023.155146. Epub 2023 Oct 17. PMID: 37918280. 7: Yang Y, Lei W, Qian L, Zhang S, Yang W, Lu C, Song Y, Liang Z, Deng C, Chen Y, Tian Y, Zhao H. Activation of NR1H3 signaling pathways by psoralidin attenuates septic myocardial injury. Free Radic Biol Med. 2023 Aug 1;204:8-19. doi: 10.1016/j.freeradbiomed.2023.04.006. Epub 2023 Apr 20. PMID: 37085126. 8: Boulebd H, Pereira DM. Examination of the Antioxidant Activity of Psoralidin: Computational Mechanistic Study and Impact on the ROS Level in Human Keratinocytes. J Org Chem. 2023 May 5;88(9):5745-5751. doi: 10.1021/acs.joc.3c00193. Epub 2023 Apr 19. PMID: 37074959. 9: Cheng S, Liu S, Chen B, Du C, Xiao P, Luo X, Wei L, Lei Y, Zhao C, Huang W. Psoralidin inhibits osteosarcoma growth and metastasis by downregulating ITGB1 expression via the FAK and PI3K/Akt signaling pathways. Chin Med. 2023 Mar 31;18(1):34. doi: 10.1186/s13020-023-00740-w. PMID: 37004120; PMCID: PMC10064721. 10: Youness RA, Al-Mahallawi AM, Mahmoud FH, Atta H, Braoudaki M, Fahmy SA. Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells. Polymers (Basel). 2023 Mar 15;15(6):1464. doi: 10.3390/polym15061464. PMID: 36987244; PMCID: PMC10052996. 11: Tang JF, Niu L, Wang XY, Zhang H, Zhang ML, Wu YL, Chen XF, Feng KR, Jia JH, Li WX. [Comparison on distribution of 8 components from ethanol extract of Psoraleae Fructus between normal and lipopolysaccharide-induced model rats]. Zhongguo Zhong Yao Za Zhi. 2022 Dec;47(24):6763-6779. Chinese. doi: 10.19540/j.cnki.cjcmm.20220823.501. PMID: 36604926. 12: Piao S, Lin H, Tao X, Chen W. Mitochondrial toxicants in Xian-Ling-Gu-Bao induce liver injury by regulating the PI3K/mTOR signaling pathway: an in vitro study. BMC Complement Med Ther. 2022 Dec 1;22(1):317. doi: 10.1186/s12906-022-03798-5. PMID: 36457007; PMCID: PMC9716976. 13: Han X, Shi Q, He Z, Song W, Chen Q, Qi Z. Transcriptome-wide N6-methyladenosine (m6A) methylation in soybean under Meloidogyne incognita infection. aBIOTECH. 2022 Aug 18;3(3):197-211. doi: 10.1007/s42994-022-00077-2. PMID: 36313932; PMCID: PMC9590533. 14: Liang Z, Chen Y, Wang Z, Wu X, Deng C, Wang C, Yang W, Tian Y, Zhang S, Lu C, Yang Y. Protective effects and mechanisms of psoralidin against adriamycin- induced cardiotoxicity. J Adv Res. 2022 Sep;40:249-261. doi: 10.1016/j.jare.2021.12.007. Epub 2021 Dec 28. PMID: 36100330; PMCID: PMC9481943. 15: Li S, Liu X, Nie Y, Yang L, Zhang C, Guo Y, Yang S, Li Z. Psoralidin Induced Differentiation from Adipose-derived Stem Cells to Nucleus Pulposus-like Cells by TGF-β/Smad Signaling. Curr Mol Med. 2023 May 30;23(7):688-697. doi: 10.2174/1566524022666220816165135. PMID: 35975860. 16: Lei W, Wu S, Zhao A, Wu Z, Ding B, Yang W, Lu C, Wu X, Li X, Zhang S, Tian Y, Yang Y. Psoralidin protects against cerebral hypoxia/reoxygenation injury: Role of GAS6/Axl signaling. Phytother Res. 2022 Jun;36(6):2628-2640. doi: 10.1002/ptr.7481. Epub 2022 May 18. PMID: 35583809. 17: Sun C, Zhao L, Wang X, Hou Y, Guo X, Lu JJ, Chen X. Psoralidin, a natural compound from Psoralea corylifolia, induces oxidative damage mediated apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2022 Jul;36(7):e23051. doi: 10.1002/jbt.23051. Epub 2022 Mar 21. PMID: 35315184. 18: Wu YL, Wang XY, Zhang H, Chen YL, Zhang ML, Chen XF, Niu L, Li WX, Tang JF. [Study on alleviating effect of Glycyrrhizae Radix et Rhizoma on Psoraleae Fructus-induced liver injury based on network pharmacology and cell experiments]. Zhongguo Zhong Yao Za Zhi. 2022 Jan;47(1):176-187. Chinese. doi: 10.19540/j.cnki.cjcmm.20211025.401. PMID: 35178925. 19: Guo Z, Li P, Wang C, Kang Q, Tu C, Jiang B, Zhang J, Wang W, Wang T. Five Constituents Contributed to the Psoraleae Fructus-Induced Hepatotoxicity via Mitochondrial Dysfunction and Apoptosis. Front Pharmacol. 2021 Dec 7;12:682823. doi: 10.3389/fphar.2021.682823. PMID: 34950022; PMCID: PMC8688997. 20: Lee A, Yang H, Kim T, Ha H, Hwang YH. Identification and pharmacokinetics of bioavailable anti-resorptive phytochemicals after oral administration of Psoralea corylifolia L. Biomed Pharmacother. 2021 Dec;144:112300. doi: 10.1016/j.biopha.2021.112300. Epub 2021 Oct 12. PMID: 34653758.