MJE3 is a spiroepoxide and cell-permeable, small-molecule inhibitor for phosphoglycerate mutase-1 (PGAM1), a glycolytic enzyme with postulated roles in cancer cell metabolism and proliferation. MJE3 displays antiproliferative effects in human breast cancer cells by inhibiting glycolysis. It is more potent in cells in vivo than in recombinant assays.
MedKoo Cat#: 571263
Name: MJE3
CAS#: 957762-36-6
Chemical Formula: C35H40N2O7
Exact Mass: 600.2836
Molecular Weight: 600.71
Elemental Analysis: C, 69.98; H, 6.71; N, 4.66; O, 18.64
The following data is based on the product molecular weight 600.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
