MedKoo Cat#: 571262 | Name: PF9238
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF9238 is a beta-secretase I inhibitor. Treatment with PF9238 results in the accumulation of autofluorescent granules in the retinas. PF9238 has a CatD potency of 12 uM in vivo.

Chemical Structure

PF9238
PF9238
CAS#1621585-17-8

Theoretical Analysis

MedKoo Cat#: 571262

Name: PF9238

CAS#: 1621585-17-8

Chemical Formula: C18H19F2N3O2S

Exact Mass: 379.1166

Molecular Weight: 379.43

Elemental Analysis: Elemental Analysis: C, 56.98; H, 5.05; F, 10.01; N, 11.07; O, 8.43; S, 8.45

Price and Availability

Size Price Availability Quantity
5mg USD 500.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
PF9238; PF-9238; PF 9238; PF-06649283; PF06649283; PF 06649283;
IUPAC/Chemical Name
(4R,4aR,6R,8aS)-8a-(2,4-difluorophenyl)-4-methyl-6-(3-methylisoxazol-5-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine
InChi Key
HVEVDFRWOQHAPJ-CKMNQQOVSA-N
InChi Code
InChI=1S/C18H19F2N3O2S/c1-9-5-16(25-23-9)15-7-13-10(2)26-17(21)22-18(13,8-24-15)12-4-3-11(19)6-14(12)20/h3-6,10,13,15H,7-8H2,1-2H3,(H2,21,22)/t10-,13+,15-,18-/m1/s1
SMILES Code
[H][C@@]12[C@@](CO[C@@H](C3=CC(C)=NO3)C2)(C4=CC=C(F)C=C4F)N=C(N)S[C@@H]1C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 379.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schwaid AG, Cornella-Taracido I. Causes and Significance of Increased Compound Potency in Cellular or Physiological Contexts. J Med Chem. 2017 Aug 18. doi: 10.1021/acs.jmedchem.7b00762. [Epub ahead of print] PubMed PMID: 28820267.