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MedKoo Cat#: 571256 | Name: RMPI-8226-38

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RMPI-8226-38 is an irreversible inhibitor of USP7. RMPI-8226-38 is a thiazole compound from the human multiple myeloma cell line RMPI-8226. Its IC50 against RMPI-8226 is 22 uM.

Chemical Structure

RMPI-8226-38
RMPI-8226-38
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 571256

Name: RMPI-8226-38

CAS#: NONE

Chemical Formula: C10H6Cl2N2OS2

Exact Mass: 303.9299

Molecular Weight: 305.19

Elemental Analysis: C, 39.36; H, 1.98; Cl, 23.23; N, 9.18; O, 5.24; S, 21.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
RMPI-8226-38; RMPI8226-38; RMPI 8226-38; RMPI-8226 38; RMPI8226 38; RMPI 8226 38
IUPAC/Chemical Name
1-(2-((3,5-dichloropyridin-4-yl)thio)thiazol-5-yl)ethan-1-one
InChi Key
LPIBKEIDTHOBCG-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H6Cl2N2OS2/c1-5(15)8-4-14-10(16-8)17-9-6(11)2-13-3-7(9)12/h2-4H,1H3
SMILES Code
CC(C1=CN=C(S1)SC2=C(Cl)C=NC=C2Cl)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Ubiquitin specific protease 7 (USP7) supports cancer by positively affecting tumor growth and negatively affecting the patient’s immune response to tumors. USP7 inhibitors thus are an avenue of interest in potential cancer treatment. USP7 plays an important role in antagonizing p53 functions through multiple mechanisms. p53 is a critical tumor suppressor, and mutations in p53 are found in more than 50% of human cancers.

Preparing Stock Solutions

The following data is based on the product molecular weight 305.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wu J, Kumar S, Wang F, Wang H, Chen L, Arsenault P, Mattern M, Weinstock J. Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies. J Med Chem. 2017 Aug 18. doi: 10.1021/acs.jmedchem.7b00498. [Epub ahead of print] PubMed PMID: 28768102.

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