MedKoo Cat#: 571253 | Name: BMH-7

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMH-7 is a p53 activator with potent antitumor activity. It regulates the p53 signaling pathway in bladder cancer cells. BMH-7 also induces apoptosis, changes cell size, and leads to cell death. BMH-7 is derived from quinazolinone, a small molecule that is able to activate the p53 tumor suppressor pathway.

Chemical Structure

BMH-7
BMH-7
CAS#379247-14-0

Theoretical Analysis

MedKoo Cat#: 571253

Name: BMH-7

CAS#: 379247-14-0

Chemical Formula: C20H21N5O

Exact Mass: 347.1746

Molecular Weight: 347.42

Elemental Analysis: C, 69.14; H, 6.09; N, 20.16; O, 4.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BMH-7; BMH7; BMH 7
IUPAC/Chemical Name
5-((3-(dimethylamino)propyl)amino)-8H-phthalazino[1,2-b]quinazolin-8-one
InChi Key
VYNPQVGFXYNKOX-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H21N5O/c1-24(2)13-7-12-21-18-14-8-3-4-9-15(14)19-22-17-11-6-5-10-16(17)20(26)25(19)23-18/h3-6,8-11H,7,12-13H2,1-2H3,(H,21,23)
SMILES Code
O=C1N(N=C(NCCCN(C)C)C2=C3C=CC=C2)C3=NC4=C1C=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
The p53 tumor suppressor pathway has been proposed as a possible avenue for cancer therapies by restricting malignant transformation through apoptosis or cell cycle arrest triggers. Such proposals have been used in the novel chemotherapeutic treatment of bladder cancer.

Preparing Stock Solutions

The following data is based on the product molecular weight 347.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang GH, Yuan JM, Qian G, Gu CX, Wei K, Mo DL, Qin JK, Peng Y, Zhou ZP, Pan CX, Su GF. Phthalazino[1,2-b]quinazolinones as p53 Activators: Cell Cycle Arrest, Apoptotic Response and Bak-Bcl-xl Complex Reorganization in Bladder Cancer Cells. J Med Chem. 2017 Aug 15. doi: 10.1021/acs.jmedchem.6b01769. [Epub ahead of print] PubMed PMID: 28745887.