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MedKoo Cat#: 571240 | Name: Tartrazine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tartrazine is an anionic, hydrophilic azo dye with an orange-yellow color used in fabrics, foods and cosmetics, and as a biological stain. It triggers amorphous aggregation in cationic myoglobin.

Chemical Structure

Tartrazine
Tartrazine
CAS#1934-21-0

Theoretical Analysis

MedKoo Cat#: 571240

Name: Tartrazine

CAS#: 1934-21-0

Chemical Formula: C16H9N4Na3O9S2

Exact Mass: 533.9504

Molecular Weight: 534.36

Elemental Analysis: C, 35.96; H, 1.70; N, 10.49; Na, 12.91; O, 26.95; S, 12.00

Price and Availability

Size Price Availability Quantity
100g USD 190.00
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Related CAS #
No Data
Synonym
Tartrazine, Yellow 5, E102, Acid Yellow 23
IUPAC/Chemical Name
1H-Pyrazole-3-carboxylic acid, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-(2-(4-sulfophenyl)diazenyl)-, sodium salt (1:3)
InChi Key
UJMBCXLDXJUMFB-GLCFPVLVSA-K
InChi Code
InChI=1S/C16H12N4O9S2.3Na/c21-15-13(18-17-9-1-5-11(6-2-9)30(24,25)26)14(16(22)23)19-20(15)10-3-7-12(8-4-10)31(27,28)29;;;/h1-8,13H,(H,22,23)(H,24,25,26)(H,27,28,29);;;/q;3*+1/p-3/b18-17+;;;
SMILES Code
O=C(C(C1/N=N/C2=CC=C(S(=O)([O-])=O)C=C2)=NN(C3=CC=C(S(=O)([O-])=O)C=C3)C1=O)[O-].[Na+].[Na+].[Na+]
Appearance
Orange to yellow solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 534.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rovina K, Siddiquee S, Shaarani SM. A Review of Extraction and Analytical Methods for the Determination of Tartrazine (E 102) in Foodstuffs. Crit Rev Anal Chem. 2017 Jul 4;47(4):309-324. doi: 10.1080/10408347.2017.1287558. Epub 2017 Jan 27. Review. PubMed PMID: 28128965. 2: Al-Shabib NA, Khan JM, Khan MS, Ali MS, Al-Senaidy AM, Alsenaidy MA, Husain FM, Al-Lohedan HA. Synthetic food additive dye "Tartrazine" triggers amorphous aggregation in cationic myoglobin. Int J Biol Macromol. 2017 May;98:277-286. doi: 10.1016/j.ijbiomac.2017.01.097. Epub 2017 Jan 24. PubMed PMID: 28130138. 3: Rafati A, Nourzei N, Karbalay-Doust S, Noorafshan A. Using vitamin E to prevent the impairment in behavioral test, cell loss and dendrite changes in medial prefrontal cortex induced by tartrazine in rats. Acta Histochem. 2017 Mar;119(2):172-180. doi: 10.1016/j.acthis.2017.01.004. Epub 2017 Jan 23. PubMed PMID: 28126192. 4: Shiralipour R, Larki A. Pre-concentration and determination of tartrazine dye from aqueous solutions using modified cellulose nanosponges. Ecotoxicol Environ Saf. 2017 Jan;135:123-129. doi: 10.1016/j.ecoenv.2016.09.038. Epub 2016 Oct 7. PubMed PMID: 27723464. 5: Meyer SK, Probert PME, Lakey AF, Axon AR, Leitch AC, Williams FM, Jowsey PA, Blain PG, Kass GEN, Wright MC. Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse. Toxicol Lett. 2017 May 5;273:55-68. doi: 10.1016/j.toxlet.2017.03.024. Epub 2017 Mar 27. PubMed PMID: 28356238; PubMed Central PMCID: PMC5429395. 6: Ogawa A, Shindo T, Kyoko H, Sadamasu Y, Sakamaki N, Uematsu Y, Monma K. Structures of Two Yellow Dyes Found in Cucumbers Pickled in Soy Sauce Colored with Tartrazine (Y4). Shokuhin Eiseigaku Zasshi. 2017;58(1):26-31. doi: 10.3358/shokueishi.58.26. PubMed PMID: 28260729. 7: Basu A, Suresh Kumar G. Studies on the interaction of the food colorant tartrazine with double stranded deoxyribonucleic acid. J Biomol Struct Dyn. 2016 May;34(5):935-42. doi: 10.1080/07391102.2015.1057766. Epub 2015 Jul 10. PubMed PMID: 26159358. 8: Dorraji PS, Jalali F. Electrochemical fabrication of a novel ZnO/cysteic acid nanocomposite modified electrode and its application to simultaneous determination of sunset yellow and tartrazine. Food Chem. 2017 Jul 15;227:73-77. doi: 10.1016/j.foodchem.2017.01.071. Epub 2017 Jan 17. PubMed PMID: 28274460. 9: Soares BM, Araújo TM, Ramos JA, Pinto LC, Khayat BM, De Oliveira Bahia M, Montenegro RC, Burbano RM, Khayat AS. Effects on DNA repair in human lymphocytes exposed to the food dye tartrazine yellow. Anticancer Res. 2015 Mar;35(3):1465-74. PubMed PMID: 25750299. 10: Li Y, Wei H, Liu R. A probe to study the toxic interaction of tartrazine with bovine hemoglobin at the molecular level. Luminescence. 2014 Mar;29(2):195-200. doi: 10.1002/bio.2510. Epub 2013 May 8. PubMed PMID: 23653408. 11: Xu H, Yang X, Li G, Zhao C, Liao X. Green Synthesis of Fluorescent Carbon Dots for Selective Detection of Tartrazine in Food Samples. J Agric Food Chem. 2015 Aug 5;63(30):6707-14. doi: 10.1021/acs.jafc.5b02319. Epub 2015 Jul 22. PubMed PMID: 26154603. 12: Athalathil S, Fortuny A, Font J, Stüber F, Bengoa C, Fabregat A. A potential application of sludge-based catalysts for the anaerobic bio-decolorization of tartrazine dye. Environ Technol. 2015;36(20):2568-76. doi: 10.1080/09593330.2015.1037361. Epub 2015 May 28. PubMed PMID: 26017547. 13: Zhang Y, Hu L, Liu X, Liu B, Wu K. Highly-sensitive and rapid detection of ponceau 4R and tartrazine in drinks using alumina microfibers-based electrochemical sensor. Food Chem. 2015 Jan 1;166:352-7. doi: 10.1016/j.foodchem.2014.06.048. Epub 2014 Jun 16. PubMed PMID: 25053067. 14: Basu A, Kumar GS. Thermodynamics of the interaction of the food additive tartrazine with serum albumins: a microcalorimetric investigation. Food Chem. 2015 May 15;175:137-42. doi: 10.1016/j.foodchem.2014.11.141. Epub 2014 Dec 2. PubMed PMID: 25577062. 15: Scott R, Mudimbi P, Miller ME, Magnuson M, Willison S, Phillips R, Harper WF Jr. Advanced Oxidation of Tartrazine and Brilliant Blue with Pulsed Ultraviolet Light Emitting Diodes. Water Environ Res. 2017 Jan 1;89(1):24-31. doi: 10.2175/106143016X14733681696167. PubMed PMID: 28236826. 16: Atlı Şekeroğlu Z, Güneş B, Kontaş Yedier S, Şekeroğlu V, Aydın B. Effects of tartrazine on proliferation and genetic damage in human lymphocytes. Toxicol Mech Methods. 2017 Jun;27(5):370-375. doi: 10.1080/15376516.2017.1296051. Epub 2017 Mar 7. PubMed PMID: 28264634. 17: Li Z, Song S, Xu L, Kuang H, Guo S, Xu C. Development of an ultrasensitive immunoassay for detecting tartrazine. Sensors (Basel). 2013 Jun 25;13(7):8155-69. doi: 10.3390/s130708155. PubMed PMID: 23799494; PubMed Central PMCID: PMC3758588. 18: dos Santos TC, Zocolo GJ, Morales DA, Umbuzeiro Gde A, Zanoni MV. Assessment of the breakdown products of solar/UV induced photolytic degradation of food dye tartrazine. Food Chem Toxicol. 2014 Jun;68:307-15. doi: 10.1016/j.fct.2014.03.025. Epub 2014 Apr 2. PubMed PMID: 24704040. 19: Qiu X, Lu L, Leng J, Yu Y, Wang W, Jiang M, Bai L. An enhanced electrochemical platform based on graphene oxide and multi-walled carbon nanotubes nanocomposite for sensitive determination of Sunset Yellow and Tartrazine. Food Chem. 2016 Jan 1;190:889-895. doi: 10.1016/j.foodchem.2015.06.045. Epub 2015 Jun 17. PubMed PMID: 26213053. 20: Zhang Y, Chang C, Guo Q, Cao H, Bai Y, Liu H. [Analysis of tartrazine aluminum lake and sunset yellow aluminum lake in foods by capillary zone electrophoresis]. Se Pu. 2014 Apr;32(4):438-42. Chinese. PubMed PMID: 25069336.

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