MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 571237 | Name: Phenylpropanolamine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phenylpropanolamine hydrochloride is a sympathomimetic that acts mainly by causing release of norpeinephrine but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.

Chemical Structure

Phenylpropanolamine hydrochloride
Phenylpropanolamine hydrochloride
CAS#154-41-6

Theoretical Analysis

MedKoo Cat#: 571237

Name: Phenylpropanolamine hydrochloride

CAS#: 154-41-6

Chemical Formula: C9H14ClNO

Exact Mass: 187.0764

Molecular Weight: 187.67

Elemental Analysis: C, 57.60; H, 7.52; Cl, 18.89; N, 7.46; O, 8.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Phenylpropanolamine hydrochloride; Nobese; Naldecon; Monydrin
IUPAC/Chemical Name
Benzenemethanol, alpha-((1R)-1-aminoethyl)-, hydrochloride, (alphaS)-rel-
InChi Key
DYWNLSQWJMTVGJ-PRCZDLBKSA-N
InChi Code
InChI=1S/C9H13NO.ClH/c1-7(10)9(11)8-5-3-2-4-6-8;/h2-7,9,11H,10H2,1H3;1H/t7-,9-;/m1./s1
SMILES Code
O[C@H]([C@H](N)C)C1=CC=CC=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 187.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Barry RH, Weiss M, Johnson JB, DeRitter E. Stability of phenylpropanolamine hydrochloride in liquid formulations containing sugars. J Pharm Sci. 1982 Jan;71(1):116-8. PubMed PMID: 7057363. 2: King TH, Mann CK, Vickers TJ. Determination of phenylpropanolamine hydrochloride and acetaminophen in pharmaceutical preparations by Raman spectroscopy. J Pharm Sci. 1985 Apr;74(4):443-7. PubMed PMID: 3999007. 3: Williams DM. Phenylpropanolamine hydrochloride. Am Pharm. 1990 Oct;NS30(10):47-50. PubMed PMID: 2239691. 4: Bacon NJ, Oni O, White RA. Treatment of urethral sphincter mechanism incompetence in 11 bitches with a sustained-release formulation of phenylpropanolamine hydrochloride. Vet Rec. 2002 Sep 28;151(13):373-6. PubMed PMID: 12403516. 5: Tan HS, Salvador GC. Assay of mixtures of phenylpropanolamine hydrochloride and caffeine in appetite suppressant formulations by high-performance liquid chromatography. J Chromatogr. 1983 May 20;261(1):111-6. PubMed PMID: 6874793. 6: Fukui A, Fujii R, Yonezawa Y, Sunada H. Analysis of the release process of phenylpropanolamine hydrochloride from ethylcellulose matrix granules. Chem Pharm Bull (Tokyo). 2002 Nov;50(11):1439-42. PubMed PMID: 12419906. 7: Schieffer GW, Smith WO, Lubey GS, Newby DG. Determination of the structure of a synthetic impurity in guaifenesin: modification of a high-performance liquid chromatographic method for phenylephrine hydrochloride, phenylpropanolamine hydrochloride, guaifenesin, and sodium benzoate in dosage forms. J Pharm Sci. 1984 Dec;73(12):1856-8. PubMed PMID: 6527278. 8: Segev G, Westropp JL, Kulik C, Lavy E. Changes in blood pressure following escalating doses of phenylpropanolamine and a suggested protocol for monitoring. Can Vet J. 2015 Jan;56(1):39-43. PubMed PMID: 25565712; PubMed Central PMCID: PMC4266053. 9: Biaggioni I, Onrot J, Stewart CK, Robertson D. The potent pressor effect of phenylpropanolamine in patients with autonomic impairment. JAMA. 1987 Jul 10;258(2):236-9. PubMed PMID: 3599310. 10: Sevgi F, Ozyazici M, Güneri T. Sustained-release dosage form of phenylpropanolamine hydrochloride. Part I: Microencapsulation and in vitro release kinetics. J Microencapsul. 1994 May-Jun;11(3):327-34. PubMed PMID: 8064556. 11: Chennakesava Rao K, Easwaramoorthi K, Arun Y, Balachandran C, Muralidhara Rao KS, Govindhan M, Emi N, Prakasam T, Perumal PT. Synthesis of BF₃ catalyzed Mannich derivatives with excellent ee from phenylpropanolamine, study of their antimicrobial activity and molecular docking. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4232-8. doi: 10.1016/j.bmcl.2015.07.096. Epub 2015 Aug 6. PubMed PMID: 26296475. 12: Feely LC, Davis SS. Correlation of phenylpropanolamine bioavailability with gastrointestinal transit by scintigraphic monitoring of 111In-labeled hydroxypropylmethylcellulose matrices. Pharm Res. 1989 Apr;6(4):274-8. PubMed PMID: 2748514. 13: Schieffer GW, Hughes DE. Simultaneous stability-indicating determination of phenylephrine hydrochloride, phenylpropanolamine hydrochloride, and guaifenesin in dosage forms by reversed-phase paired-ion high-performance liquid chromatography. J Pharm Sci. 1983 Jan;72(1):55-9. PubMed PMID: 6827465. 14: Fukui A, Fujii R, Yonezawa Y, Sunada H. Analysis of the release process of phenylpropanolamine hydrochloride from ethylcellulose matrix granules II. effects of the binder solution on the release process. Chem Pharm Bull (Tokyo). 2004 Mar;52(3):298-302. PubMed PMID: 14993750. 15: Sands CD, Jung KM, Jones DW, Kim HJ. Effect of phenylpropanolamine hydrochloride on blood pressure in Korean patients with hypertension controlled by hydrochlorothiazide. Clin Pharm. 1992 Feb;11(2):168-73. PubMed PMID: 1551298. 16: Sevgi F, Ozyazici M, Güneri T. Sustained-release dosage form of phenylpropanolamine hydrochloride (3). Application of factorial design. J Microencapsul. 1994 Jul-Aug;11(4):439-44. PubMed PMID: 7931943. 17: Fukui A, Fujii R, Yonezawa Y, Sunada H. Analysis of the release process of phenylpropanolamine hydrochloride from ethylcellulose matrix granules IV.(1)) Evaluation of the controlled release properties for in vivo and in vitro release systems. Chem Pharm Bull (Tokyo). 2007 Nov;55(11):1569-73. PubMed PMID: 17978513. 18: Liu J, Zhang F, McGinity JW. Properties of lipophilic matrix tablets containing phenylpropanolamine hydrochloride prepared by hot-melt extrusion. Eur J Pharm Biopharm. 2001 Sep;52(2):181-90. PubMed PMID: 11522484. 19: Das Gupta V, Heble AR. Quantitation of acetaminophen, chlorpheniramine maleate, dextromethorphan hydrobromide, and phenylpropanolamine hydrochloride in combination using high-performance liquid chromatography. J Pharm Sci. 1984 Nov;73(11):1553-6. PubMed PMID: 6520756. 20: Yamakawa I, Shimomura M, Hattori T, Watanabe S, Tsutsumi J, Shinoda A, Miyake Y. In vitro and in vivo evaluation of a sustained release preparation containing phenylpropanolamine hydrochloride. J Pharmacobiodyn. 1986 Dec;9(12):947-52. PubMed PMID: 3572716.

View History

Plegatil

Plegatil