MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 571215 | Name: A 81988

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A 81988 is a selective angiotensin II antagonist for type I receptors. It is a potent, competitive, non-peptidic antagonist of angiotensin AT1 receptors.

Chemical Structure

A 81988
A 81988
CAS#141887-34-5

Theoretical Analysis

MedKoo Cat#: 571215

Name: A 81988

CAS#: 141887-34-5

Chemical Formula: C23H22N6O2

Exact Mass: 414.1804

Molecular Weight: 414.47

Elemental Analysis: C, 66.65; H, 5.35; N, 20.28; O, 7.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
A 81988; A-81988; A81988; Abbott 81988; Abbott-81988
IUPAC/Chemical Name
3-Pyridinecarboxylic acid, 2-(propyl((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)amino)-
InChi Key
DLMNZGAILMQDHA-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H22N6O2/c1-2-14-29(22-20(23(30)31)8-5-13-24-22)15-16-9-11-17(12-10-16)18-6-3-4-7-19(18)21-25-27-28-26-21/h3-13H,2,14-15H2,1H3,(H,30,31)(H,25,26,27,28)
SMILES Code
O=C(C1=CC=CN=C1N(CCC)CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 414.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lee JY, Warner RB, Brune ME, Adler AL, Winn M, De B, Zydowsky TM, Opgenorth TJ, Kerkman DJ, DeBernardis JF. Cardiovascular effects of orally administered ABBOTT-81988, an angiotensin II antagonist, in conscious spontaneously hypertensive rats. Am J Hypertens. 1994 Nov;7(11):975-83. PubMed PMID: 7848624. 2: Hancock AA, Surber BW, Rotert G, Thomas S, Tasker AS, Sorensen BK, Vodenlich AD, Opgenorth TJ, Kerkman DJ, DeBernardis JF. [3H]A-81988, a potent, selective, competitive antagonist radioligand for angiotensin AT1 receptors. Eur J Pharmacol. 1994 Mar 15;267(1):49-54. PubMed PMID: 8206129. 3: Pollock DM, Polakowski JS, Divish BJ, Opgenorth TJ. Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition. Hypertension. 1993 May;21(5):660-6. PubMed PMID: 7684026. 4: Hancock AA, Buckner SA, Lee JY, Brune M, Morse PA, Oheim K, Warner RB, Winn M, Zydowsky TM, De B, et al. Receptor interactions of Abbott-81988, a highly potent, non-peptide angiotensin-II antagonist selective for type-1 receptors. J Recept Res. 1994 May;14(3-4):229-49. PubMed PMID: 8083867. 5: Lee JY, Buckner SA, Brune ME, Warner RB, Winn M, De B, Zydowsky TM, Opgenorth TJ, Kerkman DJ, Debernardis JF. Characterization of antihypertensive activity of ABBOTT-81988, a nonpeptide angiotensin II antagonist in the renal hypertensive rat. J Pharmacol Exp Ther. 1994 Jan;268(1):427-33. PubMed PMID: 8301584. 6: Solhaug MJ, Wallace MR, Granger JP. Nitric oxide and angiotensin II regulation of renal hemodynamics in the developing piglet. Pediatr Res. 1996 Mar;39(3):527-33. PubMed PMID: 8929876. 7: Madeddu P, Anania V, Varoni MV, Parpaglia PP, Demontis MP, Fattaccio MC, Palomba D, Pollock D, Glorioso N. Prevention by blockade of angiotensin subtype1-receptors of the development of genetic hypertension but not its heritability. Br J Pharmacol. 1995 Jun;115(4):557-62. PubMed PMID: 7582472; PubMed Central PMCID: PMC1908501. 8: Madeddu P, Salis MB, Emanueli C. Altered baroreflex control of heart rate in bradykinin B2-receptor knockout mice. Immunopharmacology. 1999 Dec;45(1-3):21-7. PubMed PMID: 10614985. 9: Winn M, De B, Zydowsky TM, Altenbach RJ, Basha FZ, Boyd SA, Brune ME, Buckner SA, Crowell D, Drizin I, et al. 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. J Med Chem. 1993 Sep 3;36(18):2676-88. PubMed PMID: 8410980. 10: Madeddu P, Emanueli C, Maestri R, Salis MB, Minasi A, Capogrossi MC, Olivetti G. Angiotensin II type 1 receptor blockade prevents cardiac remodeling in bradykinin B(2) receptor knockout mice. Hypertension. 2000 Jan;35(1 Pt 2):391-6. PubMed PMID: 10642330. 11: Madeddu P, Varoni MV, Palomba D, Emanueli C, Demontis MP, Glorioso N, Dessì-Fulgheri P, Sarzani R, Anania V. Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene. Circulation. 1997 Nov 18;96(10):3570-8. PubMed PMID: 9396457. 12: Madeddu P, Glorioso N. Does blockade of the renin-angiotensin system prevent heritability of genetic hypertension? Hypertension. 1995 Aug;26(2):9375. PubMed PMID: 7635550. 13: Pollock DM, Divish BJ, Polakowski JS, Opgenorth TJ. Angiotensin II receptor blockade improves renal function in rats with reduced renal mass. J Pharmacol Exp Ther. 1993 Nov;267(2):657-63. PubMed PMID: 8246138.

View History

ZD 7155 hydrochloride

ZD 7155 hydrochloride

HA-1004 HCl

HA-1004 HCl

KAF156

KAF156

HA-29

HA-29

Halometasone monohydrate

Halometasone monohydrate

Balomenib

Balomenib