A-80b is a synthesized pyridazino[4,5-b]indole derivate. A 80b shows potent and long-lasting antihypertensive activity and lowers blood pressure. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-80b shows dose-dependent inhibition of the Ca(2+)-induced contraction. A-80b exerts a hypotensive and antihypertensive effect, possibly attributable to vasodilator activity via interference with Ca2+ influx and probably Ca2+ mobilization from intracellular stores.
MedKoo Cat#: 571213
Name: A 80b
CAS#: 135561-94-3
Chemical Formula: C16H17N7
Exact Mass: 307.1545
Molecular Weight: 307.36
Elemental Analysis: C, 62.52; H, 5.58; N, 31.90
The following data is based on the product molecular weight 307.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
