A 802715 | CAS# 107767-58-8 | Antitumor agent MedKoo

MedKoo Cat#: 571203 | Name: A 802715

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A 802715 is an anti-tumor agent that causes dose-dependent protection against lipopolysaccharide induced lethal shock. It counteracts tumor necrosis factor alpha toxicity. It may regulate cell growth and damage response in human cancer tumor cells.

Chemical Structure

A 802715

CAS#107767-58-8

Theoretical Analysis

MedKoo Cat#: 571203

Name: A 802715

CAS#: 107767-58-8

Chemical Formula: C16H26N4O3

Exact Mass: 322.2005

Molecular Weight: 322.41

Elemental Analysis: C, 59.61; H, 8.13; N, 17.38; O, 14.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

A 802715; A-802715; A802715

IUPAC/Chemical Name

1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxy-5-methylhexyl)-3-methyl-7-propyl-

InChi Key

SBKAARSDXHSHSM-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H26N4O3/c1-5-9-19-11-17-13-12(19)14(21)20(15(22)18(13)4)10-7-6-8-16(2,3)23/h11,23H,5-10H2,1-4H3

SMILES Code

O=C(N1CCCCC(C)(O)C)N(C)C2=C(N(CCC)C=N2)C1=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 322.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bohm L, Theron T, Binder A. Influence of pentoxifylline, A-802710, propentofylline and A-802715 (Hoechst) on the expression of cell cycle blocks and S-phase content after irradiation damage. Biochim Biophys Acta. 2000 Dec 11;1499(1-2):1-10. PubMed PMID: 11118634. 2: Niehörster M, Schönharting M, Wendel A. A novel xanthine derivative counteracting in vivo tumor necrosis factor alpha toxicity in mice. Circ Shock. 1992 Aug;37(4):270-3. PubMed PMID: 1446384. 3: Hoffmann H, Weis M, Frank G, Birg A, Schönharting MM, Jochum M. Amelioration of endotoxin-induced acute lung injury in pigs by HWA 138 and A 80 2715: new analogs of pentoxifylline. Shock. 1995 Sep;4(3):166-70. PubMed PMID: 8574750. 4: Leist M, Auer-Barth S, Wendel A. Tumor necrosis factor production in the perfused mouse liver and its pharmacological modulation by methylxanthines. J Pharmacol Exp Ther. 1996 Mar;276(3):968-76. PubMed PMID: 8786577. 5: Entzian P, Bitter-Suermann S, Burdon D, Ernst M, Schlaak M, Zabel P. Differences in the anti-inflammatory effects of theophylline and pentoxifylline: important for the development of asthma therapy? Allergy. 1998 Aug;53(8):749-54. PubMed PMID: 9722223. 6: Semmler J, Gebert U, Eisenhut T, Moeller J, Schönharting MM, Alléra A, Endres S. Xanthine derivatives: comparison between suppression of tumour necrosis factor-alpha production and inhibition of cAMP phosphodiesterase activity. Immunology. 1993 Apr;78(4):520-5. PubMed PMID: 8388363; PubMed Central PMCID: PMC1421886. 7: Lin Y, Goebels J, Rutgeerts O, Kasran A, Van Gool S, Ceuppens J, Schönharting M, Waer M. Use of the methylxanthine derivative A802715 in transplantation immunology: I. Strong in vitro inhibitory effects on CD28-costimulated T cell activities. Transplantation. 1997 Jun 27;63(12):1813-8. PubMed PMID: 9210510. 8: Rieneck K, Diamant M, Haahr PM, Schönharting M, Bendtzen K. In vitro immunomodulatory effects of pentoxifylline. Immunol Lett. 1993 Aug;37(2-3):131-8. PubMed PMID: 7505000. 9: Lin Y, Segers C, Mikhalsky D, Schönharting M, Waer M. Xanthines: ideal immunosuppressants for combination with cyclosporine? Transplant Proc. 1996 Dec;28(6):3102. PubMed PMID: 8962202. 10: Lin Y, Segers C, Mikhalsky D, Tjandra-Maga TB, Schönharting M, Waer M. Use of the methylxanthine derivative A802715 in transplantation immunology: II. In vivo experiments. Transplantation. 1997 Jun 27;63(12):1734-8. PubMed PMID: 9210496. 11: Lin Y, Schönharting M, Goebels J, Rutgeerts O, Mikhalsky D, Waer M. Use of methylxanthines (MeXa) as immunosuppressive drugs for organ transplantation. Transplant Proc. 1997 Feb-Mar;29(1-2):1279. PubMed PMID: 9123305.