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MedKoo Cat#: 571202 | Name: Albifylline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Albifylline is a xanthine derivates and anti-asthmatic agent. It may cause a significant reduction of shock-induced leukocyte adhesions to the sinusoidal endothelium in the liver after hemorrhagic shock. In addition, it improves microvascular blood flow in the liver.

Chemical Structure

Albifylline
Albifylline
CAS#107767-55-5

Theoretical Analysis

MedKoo Cat#: 571202

Name: Albifylline

CAS#: 107767-55-5

Chemical Formula: C13H20N4O3

Exact Mass: 280.1535

Molecular Weight: 280.33

Elemental Analysis: C, 55.70; H, 7.19; N, 19.99; O, 17.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Albifylline
IUPAC/Chemical Name
1-(5-hydroxy-5-methylhexyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione
InChi Key
NWXULHNEYYFVMF-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H20N4O3/c1-13(2,20)6-4-5-7-17-11(18)9-10(15-8-14-9)16(3)12(17)19/h8,20H,4-7H2,1-3H3,(H,14,15)
SMILES Code
O=C(N1CCCCC(C)(O)C)N(C)C2=C(NC=N2)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 280.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Marzi I, Maier M, Herzog C, Bauer M. Influence of pentoxifylline and albifylline on liver microcirculation and leukocyte adhesion after hemorrhagic shock in the rat. J Trauma. 1996 Jan;40(1):90-6. PubMed PMID: 8577006. 2: Meskini N, Némoz G, Okyayuz-Baklouti I, Lagarde M, Prigent AF. Phosphodiesterase inhibitory profile of some related xanthine derivatives pharmacologically active on the peripheral microcirculation. Biochem Pharmacol. 1994 Mar 2;47(5):781-8. PubMed PMID: 8135854. 3: Sinha B, Semmler J, Eisenhut T, Eigler A, Endres S. Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids. Eur J Immunol. 1995 Jan;25(1):147-53. PubMed PMID: 7843225. 4: Sinha B, Semmler J, Haen E, Moeller J, Endres S. Radioimmunoassays for cyclic AMP cross-react with phosphodiesterase inhibitors and buffer components. J Toxicol Methods. 1995 Sep;34(1):29-36. PubMed PMID: 7496044. 5: Hand WL, Hand DL. Influence of pentoxifylline and its derivatives on antibiotic uptake and superoxide generation by human phagocytic cells. Antimicrob Agents. 1995 Jul;39(7):1574-9. PubMed PMID: 7492107; PubMed Central PMCID: PMC162784.