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MedKoo Cat#: 571196 | Name: Blastomycin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Blastomycin, also known as Antimycin A3, is an antigen for intradermal testing prepared from sterile filtrates of cultures of the filamentous form of Blastomyces dermatitidis. It acts as a fungicide, bactericide, and wood preservative.

Chemical Structure

Blastomycin
Blastomycin
CAS#522-70-3

Theoretical Analysis

MedKoo Cat#: 571196

Name: Blastomycin

CAS#: 522-70-3

Chemical Formula: C26H36N2O9

Exact Mass: 520.2421

Molecular Weight: 520.58

Elemental Analysis: C, 59.99; H, 6.97; N, 5.38; O, 27.66

Price and Availability

Size Price Availability Quantity
1mg USD 500.00 2 weeks
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Related CAS #
No Data
Synonym
Blastomycin; NSC 58239; NSC-58239; NSC58239; Antimycin A3.
IUPAC/Chemical Name
(2R-(2R*,3S*,6S*,7R*,8R*))-8-Butyl-3-(3-formamidosalicylamido)-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl isovalerate
InChi Key
PVEVXUMVNWSNIG-PDPGNHKXSA-N
InChi Code
InChI=1S/C26H36N2O9/c1-6-7-9-18-23(37-20(30)12-14(2)3)16(5)36-26(34)21(15(4)35-25(18)33)28-24(32)17-10-8-11-19(22(17)31)27-13-29/h8,10-11,13-16,18,21,23,31H,6-7,9,12H2,1-5H3,(H,27,29)(H,28,32)/t15-,16+,18-,21+,23+/m1/s1
SMILES Code
CC(C)CC(O[C@H]([C@H]1CCCC)[C@H](C)OC([C@@H](NC(C2=CC=CC(NC=O)=C2O)=O)[C@@H](C)OC1=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 520.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chaparas SD, Fuller VJ, Seligmann EB. Laboratory procedures for potency testing of blastomycin, histoplasmin, and coccidioidin. Proc Soc Exp Biol Med. 1972 Jun;140(2):556-9. PubMed PMID: 4556664. 2: SASLAW S, CAMPBELL CC. A comparison between histoplasmin and blastomycin by the collodion agglutination technique. Public Health Rep. 1949 Mar 4;64(9):290-4. PubMed PMID: 18111632. 3: SMITH JG Jr, HUMBERT WC, OLANSKY S. Follow-up of blastomycin sensitivity in an epidemic area. Public Health Rep. 1958 Jul;73(7):610-4. PubMed PMID: 13568012; PubMed Central PMCID: PMC1951696. 4: FURCOLOW ML, SCHWARZ J, HEWELL BA, GRAYSTON JT. Incidence of tuberculin, histoplasmin, and blastomycin reactors among a group of school children. Am J Public Health Nations Health. 1953 Dec;43(12):1523-31. PubMed PMID: 13104715; PubMed Central PMCID: PMC1620580. 5: Sarosi GA, King RA. Apparent diminution of the blastomycin skin test; follow-up of an epidemic of blastomycosis. Am Rev Respir Dis. 1977 Oct;116(4):785-8. PubMed PMID: 921056. 6: Lancaster MV, Sprouse RF. Preparative isotachophoretic separation of skin test antigens from blastomycin purified derivative. Infect Immun. 1976 Mar;13(3):758-62. PubMed PMID: 1270132; PubMed Central PMCID: PMC420674. 7: CORPER HJ, SHUBIN H. Tuberculin, histoplasmin, blastomycin and coccidioidin testing by a new intradermal method in 1400 patients. Tuberculol Thorac Dis. 1956 Nov;16(2):130-4. PubMed PMID: 13381031. 8: DEL CAMPO A, GHEZZO F. [Research on skin reactions to mycotic antigens; histoplasmin, coccidioidin, paracoccidioidin, blastomycin, sporotrichin and aspergillin]. Arcisp S Anna Ferrara. 1956;9(5):853-61. Italian. PubMed PMID: 13382619. 9: HOWELL A Jr. Studies of fungus antigens; quantitative studies of cross-reactions between histoplasmin and blastomycin in guinea pigs. Public Health Rep. 1947 May 2;62(18):631-51. PubMed PMID: 20340498. 10: RONEY JG Jr, BARKLEY VE, COHEN AC, PAULSEN HW. Tuberculin, histoplasmin, and blastomycin skin testing in a state college. Pa Med J. 1961 May;64:626-31. PubMed PMID: 13743128. 11: Marx MB, Jones MB, Kimberlin DS, Furcolow ML. Survey of histoplasmin and blastomycin test reactors among thoroughbred horses in central Kentucky. Am J Vet Res. 1972 Aug;33(8):1701-5. PubMed PMID: 5047123. 12: HEWELL BA, SCHWARTZ J. Epidemiologic aspects of skin reactions to tuberculin, histoplasmin and blastomycin. Cinci J Med. 1952 Jul;33(7):284-6. PubMed PMID: 14936174. 13: LUCASSE C, DUQUENOY JJ, OTTEN AE. [Intradermoreactions to histoplasmin in a Congolese population as compared with coccidioidin, blastomycin and tuberculin]. Ann Soc Belg Med Trop (1920). 1957 Oct 31;37(5):647-77. Dutch. PubMed PMID: 13509438. 14: PAYNTER HS. Deep mucoses in Hawaii; histoplasmin, coccidioidin, haplosporangin and blastomycin sensitivity and a review of cases of mycoses. Hawaii Med J. 1954 Jan-Feb;13(3):189-94. PubMed PMID: 13128580. 15: Islam N, Sobhan MA. Sensitivity to histoplasmin, coccidioidin, blastomycin, and tuberculin in East Pakistan. Am J Trop Med Hyg. 1971 Jul;20(4):621-4. PubMed PMID: 5568129. 16: Kuate S, Marino MP, Reiser J. Analysis of partial recombinants in lentiviral vector preparations. Hum Gene Ther Methods. 2014 Apr;25(2):126-35. doi: 10.1089/hgtb.2013.015. Epub 2014 Feb 14. PubMed PMID: 24367910; PubMed Central PMCID: PMC3991964. 17: Klein BS, Bradsher RW, Vergeront JM, Davis JP. Development of long-term specific cellular immunity after acute Blastomyces dermatitidis infection: assessments following a large point-source outbreak in Wisconsin. J Infect Dis. 1990 Jan;161(1):97-101. PubMed PMID: 2295863. 18: Smith CD, Furcolow ML, Hulker PW. Distribution of Blastomyces dermatitidis in dogs with skin test and serologic results following airborne infection. Sabouraudia. 1975 Jul;13(2):192-9. PubMed PMID: 1162541. 19: Recht LD, Philips JR, Eckman MR, Sarosi GA. Self-limited blastomycosis: a report of thirteen cases. Am Rev Respir Dis. 1979 Nov;120(5):1109-12. PubMed PMID: 507527. 20: Dolan MJ, Cox RA. Production and characterization of a monoclonal antibody to the complement fixation antigen of Coccidioides immitis. Infect Immun. 1991 Jun;59(6):2175-80. PubMed PMID: 1709921; PubMed Central PMCID: PMC257983.