A 75998 | CAS# 135215-95-1

MedKoo Cat#: 571187 | Name: A 75998

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A 75998 is an inhibitor of leuteinizing hormone-releasing hormone. It is a synthetic antagonist of leuteinizing hormone releasing hormone with potential for treatment of hormone-sensitive cancers and endometriosis.

Chemical Structure

A 75998

CAS#135215-95-1

Theoretical Analysis

MedKoo Cat#: 571187

Name: A 75998

CAS#: 135215-95-1

Chemical Formula: C82H110ClN15O15

Exact Mass: 1579.7994

Molecular Weight: 1581.32

Elemental Analysis: C, 62.28; H, 7.01; Cl, 2.24; N, 13.29; O, 15.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

A 75998; A-75998; A75998

IUPAC/Chemical Name

N-Acetyl-D-2-naphthylalanyl-4-chlorophenylalanyl-3-pyridylalanyl-seryl-N-methyltyrosyl-N(epsilon)-nicotinyllysyl-leucyl-N(epsilon)-isopropyllysyl-prolyl-alaninamide acetate

InChi Key

CHTZXZAMVXTFNE-DVKQQPHFSA-N

InChi Code

InChI=1S/C80H106ClN15O13.C2H4O2/c1-48(2)39-67(80(109)96(62-31-27-57-18-10-11-19-58(57)42-62)52(7)71(100)59(45-86-49(3)4)28-34-66(89-53(8)98)79(108)95-38-16-22-69(95)76(105)88-50(5)72(101)90-61-20-15-37-85-46-61)92-75(104)65(21-12-13-35-83-43-56-17-14-36-84-44-56)91-77(106)70(41-55-25-32-63(99)33-26-55)94(9)78(107)68(47-97)93-73(102)51(6)87-74(103)64(82)40-54-23-29-60(81)30-24-54;1-2(3)4/h10-11,14-15,17-20,23-27,29-33,36-37,42,44,46,48-52,59,64-70,83,86,97,99H,12-13,16,21-22,28,34-35,38-41,43,45,47,82H2,1-9H3,(H,87,103)(H,88,105)(H,89,98)(H,90,101)(H,91,106)(H,92,104)(H,93,102);1H3,(H,3,4)/t50-,51-,52-,59?,64-,65-,66-,67-,68-,69-,70-;/m0./s1

SMILES Code

C[C@@H](C(NC1=CC=CN=C1)=O)NC([C@H]2N(C([C@H](CCC(C([C@H](C)N(C([C@H](CC(C)C)NC([C@H](CCCCNCC3=CN=CC=C3)NC([C@H](CC4=CC=C(O)C=C4)N(C([C@H](CO)NC([C@H](C)NC([C@H](CC5=CC=C(Cl)C=C5)N)=O)=O)=O)C)=O)=O)=O)C6=CC=C7C=CC=CC7=C6)=O)CNC(C)C)NC(C)=O)=O)CCC2)=O.CC(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,581.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Haviv F, Bush EN, Knittle J, Greer J. LHRH antagonists. Pharm Biotechnol. 1998;11:131-49. Review. PubMed PMID: 9760679. 2: Cannon JB, Krill SL, Porter WR. Physicochemical properties of A-75998, an antagonist of luteinizing hormone releasing hormone. J Pharm Sci. 1995 Aug;84(8):953-8. PubMed PMID: 7500280. 3: Haviv F, Fitzpatrick TD, Nichols CJ, Bush EN, Diaz G, Bammert G, Nguyen AT, Johnson ES, Knittle J, Greer J. In vitro and in vivo activities of reduced-size antagonists of luteinizing hormone-releasing hormone. J Med Chem. 1994 Mar 4;37(5):701-5. PubMed PMID: 7510341.