MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 561357 | Name: Ginsenoside Ro
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ginsenoside Ro is a triterpenoid saponin classified as an oleanane-type ginsenoside, derived from the roots of Panax species, particularly Panax ginseng and Panax notoginseng. It exhibits pharmacological activity by modulating inflammatory signaling pathways, notably through inhibition of NF-κB activation and reduction of pro-inflammatory cytokine production. Unlike the more commonly studied dammarane-type ginsenosides (e.g., Rb1, Rg1), Ro has distinct structural and metabolic properties, contributing to its unique immunomodulatory and hepatoprotective effects.

Chemical Structure

Ginsenoside Ro
Ginsenoside Ro
CAS#34367-04-9

Theoretical Analysis

MedKoo Cat#: 561357

Name: Ginsenoside Ro

CAS#: 34367-04-9

Chemical Formula: C48H76O19

Exact Mass: 956.4981

Molecular Weight: 957.12

Elemental Analysis: C, 60.24; H, 8.00; O, 31.76

Price and Availability

Size Price Availability Quantity
5mg USD 250.00 2 Weeks
10mg USD 450.00 2 Weeks
25mg USD 850.00 2 Weeks
50mg USD 1,350.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Ginsenoside Ro; ginsenoside-Ro; Chikusetsusaponin 5; Chikusetsusaponin V; Polysciasaponin P3;
IUPAC/Chemical Name
(2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4-dihydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2-carboxylic acid
InChi Key
NFZYDZXHKFHPGA-QQHDHSITSA-N
InChi Code
InChI=1S/C48H76O19/c1-43(2)14-16-48(42(61)67-40-35(58)31(54)29(52)24(20-50)63-40)17-15-46(6)21(22(48)18-43)8-9-26-45(5)12-11-27(44(3,4)25(45)10-13-47(26,46)7)64-41-37(33(56)32(55)36(65-41)38(59)60)66-39-34(57)30(53)28(51)23(19-49)62-39/h8,22-37,39-41,49-58H,9-20H2,1-7H3,(H,59,60)/t22-,23+,24+,25-,26+,27-,28+,29+,30-,31-,32-,33-,34+,35+,36-,37+,39-,40-,41+,45-,46+,47+,48-/m0/s1
SMILES Code
C(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)(=O)[C@]23[C@](C=4[C@@](C)(CC2)[C@@]5(C)[C@](CC4)([C@]6(C)[C@@](CC5)(C(C)(C)[C@@H](O[C@H]7[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O7)CC6)[H])[H])(CC(C)(C)CC3)[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 957.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li Y, Wang T, Li H, Jiang Y, Shen X, Kang N, Guo Z, Zhang R, Lu X, Kang T, Li M, Hou Y, Wu Y. Targeting LKB1-AMPK-SIRT1-induced autophagy and mitophagy pathways improves cerebrovascular homeostasis in APP/PS1 mice. Free Radic Biol Med. 2025 Apr 1;233:400-418. doi: 10.1016/j.freeradbiomed.2025.03.045. Epub ahead of print. PMID: 40180019. 2: Li T, Chen J, Xie Z, Fang J, Wu Q, Cao X, Chen Z, Wang Y, Fan Q, Wang Q, Liu J. Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway. Front Pharmacol. 2025 Feb 24;16:1528590. doi: 10.3389/fphar.2025.1528590. PMID: 40066331; PMCID: PMC11891224. 3: Ren JL, Zhang XL, Zhao LJ, Wen GY, Liu JF, Meng QY, Yang Z, Song LL, Zhang YJ. Unveiling the neuroprotective mystery of Kaixinsan: identifying and validating the neuroprotective ingredients under the perspective of gut - brain axis regulation. J Asian Nat Prod Res. 2025 Mar 3:1-18. doi: 10.1080/10286020.2025.2468310. Epub ahead of print. PMID: 40029107. 4: Cui X, Wang Y, Liu Z, Zhao M, Zhu M, Yu W, Lu B, Xu H, Liu J, Liao N, Shi J, Peng D, Niu S, Shen J, Qiu J, Yu L. Ginsenoside Ro improves Salmonella Typhimurium-induced colitis through inhibition of the virulence factors SopB and SopE2 via the RAC1/CDC42/ARP2/3 pathway. FASEB J. 2024 Dec 13;38(24):e70282. doi: 10.1096/fj.202401712R. PMID: 39734277; PMCID: PMC11695707. 5: Liu J, Zhang Y, Xu X, Dong X, Pan Y, Sun X, Luo Y. Ginsenoside Ro prevents endothelial injury via promoting Epac1/AMPK- mediated mitochondria protection in early diabetic retinopathy. Pharmacol Res. 2025 Jan;211:107562. doi: 10.1016/j.phrs.2024.107562. Epub 2024 Dec 26. PMID: 39732351. 6: Liu S, Ai Z, Hu Y, Ren G, Zhang J, Tang P, Zou H, Li X, Wang Y, Nan B, Wang Y. Ginseng glucosyl oleanolate inhibit cervical cancer cell proliferation and angiogenesis via PI3K/AKT/HIF-1α pathway. NPJ Sci Food. 2024 Dec 19;8(1):105. doi: 10.1038/s41538-024-00341-3. Erratum in: NPJ Sci Food. 2025 Mar 25;9(1):40. doi: 10.1038/s41538-025-00382-2. PMID: 39702347; PMCID: PMC11659631. 7: Wang Q, Li MJ, Guo XM, Zhang ZK, Zhang N, Wang ZM, Gong MX. [Differences in components and anti-inflammatory and analgesic activities of two phase states of Wuzhuyu Decoction]. Zhongguo Zhong Yao Za Zhi. 2024 Nov;49(21):5865-5876. Chinese. doi: 10.19540/j.cnki.cjcmm.20240719.301. PMID: 39701796. 8: Xia SL, Wei Y, Jiang XM, Xu J, Li Y, Zhu YL, Wang Y, Deng R, Wu H. [Main active components and mechanism of Sanmiao Pills in treating rheumatoid arthritis]. Zhongguo Zhong Yao Za Zhi. 2024 Oct;49(19):5204-5217. Chinese. doi: 10.19540/j.cnki.cjcmm.20240716.303. PMID: 39701758. 9: Chen ZX, Li L, Tang J, Shi MG, Lim XY, Song PR, Zou L, Han H, Gu Y, Zhang T. Metabolite profiling of Shenhua compound in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal. 2025 Mar 15;255:116626. doi: 10.1016/j.jpba.2024.116626. Epub 2024 Dec 9. PMID: 39671911. 10: Luo X, Ye Z, Shi X, Hu Z, Shen J, You L, Huang P, Wang G, Zheng L, Li C, Zhang Y. Comparative transcriptomic analysis provides insights into the regulation of root-specific saponin production in Panax japonicus. Sci Rep. 2024 Nov 11;14(1):27572. doi: 10.1038/s41598-024-78720-9. PMID: 39528625; PMCID: PMC11555050. 11: Zhu R, Gao Z, Wu S, Ma S, Zhu Y, Zhang S, Zhang Y, Zeng H, Ma C, Zhao J, Ye J, Zhang W. Multi-omics and network pharmacology approaches reveal Gui-Ling-Ji alleviates oligoasthenoteratozoospermia by regulating arachidonic acid pathway. Phytomedicine. 2024 Dec;135:156184. doi: 10.1016/j.phymed.2024.156184. Epub 2024 Oct 28. PMID: 39488872. 12: Yang Q, Xiong C, Zhang J, Ming Y, Zhang S, Wang L, Wang H, Xu R, Wang B. Chemical and Transcriptomic Analyses Provide New Insights into Key Genes for Ginsenoside Biosynthesis in the Rhizome of Panax japonicus C. A. Meyer. Molecules. 2024 Oct 18;29(20):4936. doi: 10.3390/molecules29204936. PMID: 39459304; PMCID: PMC11510602. 13: Yu X, Yu J, Wang D, Liu S, Wang K, Zhao M, Chen P, Wang Y, Wang Y, Zhang M. A Novel Biosynthetic Strategy for Ginsenoside Ro: Construction of a Metabolically Engineered Saccharomyces cerevisiae Strain Using a Newly Identified UGAT Gene from Panax ginseng as the Key Enzyme Gene and Optimization of Fermentation Conditions. Int J Mol Sci. 2024 Oct 21;25(20):11331. doi: 10.3390/ijms252011331. PMID: 39457113; PMCID: PMC11509030. 14: Jiang X, Qin Y, Wang H, Jia Z, Liu Y, Xiong Z, Zhao L. Cell Membrane- Camouflaged Biomimetic Magnetic Fluorescent Nanoparticles with Enhanced Stability for High-Performance Lead Drug Discovery. Anal Chem. 2024 Sep 15. doi: 10.1021/acs.analchem.4c02695. Epub ahead of print. PMID: 39279132. 15: Wu Z, Dou W, Yang X, Niu T, Han Z, Yang L, Wang R, Wang Z. Novel glycosidase from Paenibacillus lactis 154 hydrolyzing the 28-O-β-D-glucopyranosyl ester bond of oleanane-type saponins. Appl Microbiol Biotechnol. 2024 Apr 4;108(1):282. doi: 10.1007/s00253-024-13109-2. PMID: 38573330; PMCID: PMC10995091. 16: Ai Z, Liu S, Zhang J, Hu Y, Tang P, Cui L, Wang X, Zou H, Li X, Liu J, Nan B, Wang Y. Ginseng Glucosyl Oleanolate from Ginsenoside Ro, Exhibited Anti-Liver Cancer Activities via MAPKs and Gut Microbiota In Vitro/Vivo. J Agric Food Chem. 2024 Apr 10;72(14):7845-7860. doi: 10.1021/acs.jafc.3c08150. Epub 2024 Mar 19. PMID: 38501913. 17: Yu X, Yu J, Liu S, Liu M, Wang K, Zhao M, Wang Y, Chen P, Lei J, Wang Y, Zhang M. Transcriptome-Wide Identification and Integrated Analysis of a UGT Gene Involved in Ginsenoside Ro Biosynthesis in Panax ginseng. Plants (Basel). 2024 Feb 23;13(5):604. doi: 10.3390/plants13050604. PMID: 38475452; PMCID: PMC10935288. 18: Xu H, Lu X, Li M, Huang X, Yao N, Gan H, Huang X, Zhao Z, Hu Z, Zhao X, Lai Y, Li M, Chen S, Chen Y, Huang D. Jiangu formula: A novel osteoclast-osteoblast coupling agent for effective osteoporosis treatment. Phytomedicine. 2024 Jun;128:155501. doi: 10.1016/j.phymed.2024.155501. Epub 2024 Feb 28. PMID: 38471318. 19: Luo S, Yang X, Zhang Y, Kuang T, Tang C. Spatial metabolomics method to reveal differential metabolomes in microregions of Panax quinquefolius roots by using ultra-performance liquid chromatography quadrupole/time of flight-mass spectrometry and desorption electrospray ionization mass spectrometry imaging. Food Chem. 2024 Mar 1;435:137504. doi: 10.1016/j.foodchem.2023.137504. Epub 2023 Oct 5. PMID: 37813026. 20: Yang Y, Shen L, Wang P, Tao Y. Anti-osteoporosis bioactivity evaluation in zebrafish model of raw and salt-processed Achyranthes bidentata followed by liquid chromatography-mass spectrometry analysis and correlation analysis. Biomed Chromatogr. 2023 Dec;37(12):e5742. doi: 10.1002/bmc.5742. Epub 2023 Sep 7. PMID: 37674471.