MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 561342 | Name: PF-6422899
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-6422899 is an irreversible inhibitor of EGFR kinase activity. PF-6422899 binds covalently to active-site cysteine residues in the ATP binding pocket of EGFR.

Chemical Structure

PF-6422899
PF-6422899
CAS#1621002-23-0

Theoretical Analysis

MedKoo Cat#: 561342

Name: PF-6422899

CAS#: 1621002-23-0

Chemical Formula: C20H14ClFN4O2

Exact Mass: 396.0789

Molecular Weight: 396.81

Elemental Analysis: \C, 60.54; H, 3.56; Cl, 8.93; F, 4.79; N, 14.12; O, 8.06

Price and Availability

Size Price Availability Quantity
5mg USD 475.00 2 Weeks
25mg USD 1,060.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
PF-6422899; PF6422899; PF 6422899;
IUPAC/Chemical Name
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-(2-propyn-1-yloxy)-6-quinazolinyl]-2-propenamide
InChi Key
AZLXGJFHSLQCPV-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H14ClFN4O2/c1-3-7-28-18-10-16-13(9-17(18)26-19(27)4-2)20(24-11-23-16)25-12-5-6-15(22)14(21)8-12/h1,4-6,8-11H,2,7H2,(H,26,27)(H,23,24,25)
SMILES Code
C=CC(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC#C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
PF-6422899 is an irreversible inhibitor of EGFR kinase activity.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 396.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
van Bergen W, Žuna K, Fiala J, Pohl EE, Heck AJR, Baggelaar MP. Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs. ACS Chem Biol. 2024 Aug 16;19(8):1705-1718. doi: 10.1021/acschembio.3c00637. Epub 2024 Jul 25. PMID: 39052621; PMCID: PMC11334109.