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MedKoo Cat#: 561328 | Name: Hippuristanol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hippuristanol is a potent steroid inhibitor of eukaryotic initiation factor 4A (eIF4A). eIF4A is an essential RNA helicase involved in translation initiation.

Chemical Structure

Hippuristanol
Hippuristanol
CAS#80442-78-0

Theoretical Analysis

MedKoo Cat#: 561328

Name: Hippuristanol

CAS#: 80442-78-0

Chemical Formula: C28H46O5

Exact Mass: 462.3345

Molecular Weight: 462.67

Elemental Analysis: C, 72.69; H, 10.02; O, 17.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Hippuristanol;
IUPAC/Chemical Name
(3R,5S,11S,20R,22S,24S)-24-Methyl-22,25-epoxyfurostan-3,11,20-triol
InChi Key
HPHXKNOXVBFETI-FELJEYOCSA-N
InChi Code
InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28-/m0/s1
SMILES Code
[H][C@]1(O[C@@](C[C@H](C)C2(C)C)(O2)[C@@]3(O)C)C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@H](O)CC[C@]6(C)[C@@]5([H])[C@@H](O)C[C@]4(C)[C@]13[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 462.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cencic R, Pelletier J. Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A. Translation (Austin). 2016 Jan 4;4(1):e1137381. doi: 10.1080/21690731.2015.1137381. eCollection 2016 Jan-Jun. Review. PubMed PMID: 27335721; PubMed Central PMCID: PMC4909409. 2: Raza F, Waldron JA, Quesne JL. Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence. Biochem Soc Trans. 2015 Dec;43(6):1227-33. doi: 10.1042/BST20150163. Review. PubMed PMID: 26614665. 3: Lindqvist L, Pelletier J. Inhibitors of translation initiation as cancer therapeutics. Future Med Chem. 2009 Dec;1(9):1709-22. doi: 10.4155/fmc.09.122. Review. PubMed PMID: 21425987.