MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 561325 | Name: Picloram
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Picloram is a systemic herbicide used for general woody plant control. It also controls a wide range of broad-leaved weeds, but most grasses are resistant.

Chemical Structure

Picloram
Picloram
CAS#1918-02-1

Theoretical Analysis

MedKoo Cat#: 561325

Name: Picloram

CAS#: 1918-02-1

Chemical Formula: C6H3Cl3N2O2

Exact Mass: 239.9260

Molecular Weight: 241.45

Elemental Analysis: C, 29.85; H, 1.25; Cl, 44.05; N, 11.60; O, 13.25

Price and Availability

Size Price Availability Quantity
5g USD 230.00
25g USD 500.00
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Picloram; Tordon; Grazon;
IUPAC/Chemical Name
4-Amino-3,5,6-trichloro-2-pyridinecarboxylic acid
InChi Key
NQQVFXUMIDALNH-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H3Cl3N2O2/c7-1-3(10)2(8)5(9)11-4(1)6(12)13/h(H2,10,11)(H,12,13)
SMILES Code
O=C(C1=NC(Cl)=C(Cl)C(N)=C1Cl)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Picloram is an auxinic herbicide that is widely used for controlling broad leaf weeds.
In vitro activity:
This study investigated the interaction between the widely used pesticide picloram with Langmuir monolayers of binary and ternary mixtures comprising 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), sphingomyelin (SM) and cholesterol (Chol), which could be taken as representative of ocular membranes in humans. Picloram expanded the molecular area of DOPC/SM and DOPC/SM/Chol monolayers as the pesticide penetrated the hydrophobic region of the mixtures. Reference: Colloids Surf B Biointerfaces. 2019 Sep 1;181:953-958. https://pubmed.ncbi.nlm.nih.gov/31382345/
In vivo activity:
Treatment of male rats with equivalent doses of 2-acetylaminofluorene, 2-amino-anthracene and picloram induced ethoxyresorufin-O-deethylase activity to the same degree. Treatment of female rats with picloram resulted in dose-dependent increases in ethoxyresorufin and ethoxycoumarin-O-deethylation without decreasing aldrin epoxidase activity. Picloram binds to liver microsomal preparations from rats pretreated with phenobarbitone and/or 3-methylcholanthrene, giving a type I spectrum. Reference: Xenobiotica. 1987 Sep;17(9):1057-66. https://pubmed.ncbi.nlm.nih.gov/3687062/
Solvent mg/mL mM comments
Solubility
DMSO 100.0 414.16
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 241.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Lemma T, Marques Ruiz GC, Oliveira ON Jr, Constantino CJL. The pesticide picloram affects biomembrane models made with Langmuir monolayers. Colloids Surf B Biointerfaces. 2019 Sep 1;181:953-958. doi: 10.1016/j.colsurfb.2019.06.060. Epub 2019 Jun 26. PMID: 31382345. 2.Reidy GF, Rose HA, Stacey NH. Effects of picloram on xenobiotic biotransformation in rat liver. Xenobiotica. 1987 Sep;17(9):1057-66. doi: 10.3109/00498258709044204. PMID: 3687062.
In vitro protocol:
Lemma T, Marques Ruiz GC, Oliveira ON Jr, Constantino CJL. The pesticide picloram affects biomembrane models made with Langmuir monolayers. Colloids Surf B Biointerfaces. 2019 Sep 1;181:953-958. doi: 10.1016/j.colsurfb.2019.06.060. Epub 2019 Jun 26. PMID: 31382345.
In vivo protocol:
Reidy GF, Rose HA, Stacey NH. Effects of picloram on xenobiotic biotransformation in rat liver. Xenobiotica. 1987 Sep;17(9):1057-66. doi: 10.3109/00498258709044204. PMID: 3687062.
1: Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Tenth Biennial Update), Board on the Health of Select Populations, Institute of Medicine, National Academies of Sciences, Engineering, and Medicine. Veterans and Agent Orange: Update 2014. Washington (DC): National Academies Press (US); 2016 Mar 29. PubMed PMID: 27099897. 2: Wicaksono A, Mursidawati S, Sukamto LA, Teixeira da Silva JA. Rafflesia spp.: propagation and conservation. Planta. 2016 Aug;244(2):289-96. doi: 10.1007/s00425-016-2512-8. Epub 2016 Apr 8. Review. PubMed PMID: 27059028. 3: Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update), Board on the Health of Select Populations, Institute of Medicine. Veterans and Agent Orange: Update 2012. Washington (DC): National Academies Press (US); 2014 Mar 6. PubMed PMID: 24716252. 4: Wells MJ, Yu LZ. Solid-phase extraction of acidic herbicides. J Chromatogr A. 2000 Jul 14;885(1-2):237-50. Review. PubMed PMID: 10941675. 5: Picloram. IARC Monogr Eval Carcinog Risks Hum. 1991;53:481-93. Review. PubMed PMID: 1842589. 6: Reuber MD. Carcinogenicity of picloram. J Toxicol Environ Health. 1981 Feb;7(2):207-22. Review. PubMed PMID: 7014921. 7: Horowitz M. Bioassay techniques for foliar-applied herbicides. Residue Rev. 1976;61:113-23. Review. PubMed PMID: 778954.