Lintopride | CAS#107429-63-0 | 5HT-4 antagonist

MedKoo Cat#: 561319 | Name: Lintopride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lintopride is a 5HT-4 antagonist with moderate 5HT-3 antagonist properties. Treatment with Lintopride significantly increases the lower oesophageal sphincter (LOS) basal tone without affecting LOS physiological relaxation after swallowing in humans.

Chemical Structure

Lintopride

CAS#107429-63-0

Theoretical Analysis

MedKoo Cat#: 561319

Name: Lintopride

CAS#: 107429-63-0

Chemical Formula: C14H19ClN4O2

Exact Mass: 310.1197

Molecular Weight: 310.78

Elemental Analysis: C, 54.11; H, 6.16; Cl, 11.41; N, 18.03; O, 10.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Lintopride;

IUPAC/Chemical Name

4-Amino-5-chloro-N-[(1-ethyl-4,5-dihydroimidazol-2-yl)methyl]-2-methoxybenzamide

InChi Key

MJCKISCWHDATBN-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H19ClN4O2/c1-3-19-5-4-17-13(19)8-18-14(20)9-6-10(15)11(16)7-12(9)21-2/h6-7H,3-5,8,16H2,1-2H3,(H,18,20)

SMILES Code

O=C(NCC1=NCCN1CC)C2=CC(Cl)=C(N)C=C2OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 310.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Goldhill J, Porquet MF, Angel I. Post-synaptic 5-HT4 receptor modulation of tachykinergic excitation of rat oesophageal tunica muscularis mucosae. Eur J Pharmacol. 1997 Apr 4;323(2-3):229-33. PubMed PMID: 9128843. 2: Delvaux M, Maisin JM, Arany Y, Atlan P, Prieto-Cabanis MJ, Canal M, Frexinos J. The effects of lintopride, a 5HT-4 antagonist, on oesophageal motility. Aliment Pharmacol Ther. 1995 Oct;9(5):563-9. PubMed PMID: 8580279. 3: Bressolle F, Bres J, Moulin A. High-performance liquid chromatographic determination of 4-amino-5-chloro-N-[(1-ethylimidazolin-2-yl)methyl]-2-methoxybenzamide and its metabolite in biological fluids. Applications in pharmacokinetic studies. J Pharm Sci. 1990 Jun;79(6):534-9. PubMed PMID: 2395100.