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MedKoo Cat#: 561304 | Name: Urolithin A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Urolithin A is an inducer of mitophagy. Urolithin A shifts mitochondria from CI- to CII-driven respiration, extends lifespan and improves muscle function.

Chemical Structure

Urolithin A
Urolithin A
CAS#1143-70-0

Theoretical Analysis

MedKoo Cat#: 561304

Name: Urolithin A

CAS#: 1143-70-0

Chemical Formula: C13H8O4

Exact Mass: 228.0423

Molecular Weight: 228.20

Elemental Analysis: C, 68.42; H, 3.53; O, 28.04

Price and Availability

Size Price Availability Quantity
5mg USD 250.00 2 Weeks
10mg USD 450.00 2 Weeks
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Related CAS #
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Synonym
Urolithin A
IUPAC/Chemical Name
3,8-Dihydroxybenzo[c]chromen-6-one
InChi Key
RIUPLDUFZCXCHM-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
SMILES Code
O=C1C2=CC(O)=CC=C2C3=C(O1)C=C(O)C=C3
Appearance
White to off-white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 228.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li F, Luo J, Xie Q, He L, Li W, Yang R, Li M. Differential effects of ellagic acid on non-alcoholic fatty liver disease in mice: grouped by urolithin A-producing capacity. Food Funct. 2025 Apr 2. doi: 10.1039/d5fo00440c. Epub ahead of print. PMID: 40171675. 2: Kshirsagar S, Reddy AP, Reddy PH. Beneficial effects of mitophagy enhancers on amyloid beta-induced mitochondrial and synaptic toxicities in Alzheimer's disease. Mitochondrion. 2025 Mar 27;83:102038. doi: 10.1016/j.mito.2025.102038. Epub ahead of print. PMID: 40157622. 3: Huang Z, Ren Z, Wang S, Xiao L, Ling Y, Xie Y, Wang G, Zhou B. Urolithin A alleviates schizophrenic-like behaviors and cognitive impairment in rats through modulation of neuroinflammation, neurogenesis, and synaptic plasticity. Sci Rep. 2025 Mar 26;15(1):10477. doi: 10.1038/s41598-025-93554-9. PMID: 40140679; PMCID: PMC11947095. 4: Akhtar A, Shakir M, Ansari MS, Divya, Faizan MI, Chauhan V, Singh A, Alam R, Azmi I, Sharma S, Pracha M, Uddin IM, Bashir U, Shahni SN, Chaudhuri R, Albogami S, Ganguly R, Sagar S, Singh VP, Kharya G, Srivastava AK, Mabalirajan U, Roy SS, Rahman I, Ahmad T. Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity. Cell Rep Med. 2025 Mar 18;6(3):102021. doi: 10.1016/j.xcrm.2025.102021. PMID: 40107240. 5: Zhang G, Zhang Z, Gong Z, Liang X, Ning T. Comment on: "Urolithin a ameliorates schizophrenia-like behaviors and cognitive impairments in female rats by modulating NLRP3 signaling". Int Immunopharmacol. 2025 Mar 17;153:114464. doi: 10.1016/j.intimp.2025.114464. Epub ahead of print. PMID: 40101417. 6: Chang Z, Wang Z, Chen Y, Liu Y, Gao Y, Cui Y, Wang L, Liu Y, Cheng R, Liu R, Zhang L. Metabolism profiles of tannins in Phyllanthus emblica L. and its immunotherapeutic potential against hepatocellular carcinoma by re-educating tumor microenvironment. Phytomedicine. 2025 May;140:156576. doi: 10.1016/j.phymed.2025.156576. Epub 2025 Mar 2. PMID: 40085988. 7: Mytilinaiou E, Kitopoulou K, Palikaras K. Caenorhabditis elegans as a Screening Platform for Anti-aging Compounds. Methods Mol Biol. 2025;2906:301-313. doi: 10.1007/978-1-0716-4426-3_18. PMID: 40082364. 8: E Y, Wang Z, Nie J. Determination of Urolithin A in Health Products by Ultra- High-Performance Liquid Chromatography. Molecules. 2025 Mar 3;30(5):1141. doi: 10.3390/molecules30051141. PMID: 40076364; PMCID: PMC11901897. 9: Wei C, Chang D, Feng N, Zhan Z, Shi L. A Unified Approach to Lactonization/Lactamization by Leveraging Tether-Tunable Distonic Radical Anions. Org Lett. 2025 Mar 21;27(11):2582-2586. doi: 10.1021/acs.orglett.5c00185. Epub 2025 Mar 12. PMID: 40072004. 10: Wang Z, Liu X, Liu S, Zhou W, Chen T, Gao S, Wu H, Zhang W, Tang R, Fang Y. Function Identification of a Lactonase Gene lac1563 Involved in Producing Urolithin A of Limosilactobacillus fermentum FUA033. J Agric Food Chem. 2025 Mar 19;73(11):6795-6806. doi: 10.1021/acs.jafc.4c10908. Epub 2025 Mar 10. PMID: 40062842. 11: Liu S, Faitg J, Tissot C, Konstantopoulos D, Laws R, Bourdier G, Andreux PA, Davey T, Gallart-Ayala H, Ivanisevic J, Singh A, Rinsch C, Marcinek DJ, D'Amico D. Urolithin A provides cardioprotection and mitochondrial quality enhancement preclinically and improves human cardiovascular health biomarkers. iScience. 2025 Jan 14;28(2):111814. doi: 10.1016/j.isci.2025.111814. PMID: 40034121; PMCID: PMC11875685. 12: Rodríguez-García A, Ancos-Pintado R, García-Vicente R, Ortiz-Ruiz A, Arroyo A, Navarro MÁ, Morales ML, Guevara-Ramirez P, Justo P, López-Muñoz N, Sánchez- Pina J, Alonso R, Selma MV, Frutos-Lisón MD, García-Villalba R, Tomás-Barberán FA, Ayala R, Martínez-López J, Linares M. Microbiota-derived urolithin A in monoclonal gammopathies and multiple myeloma therapy. Microbiome. 2025 Feb 28;13(1):56. doi: 10.1186/s40168-025-02045-6. PMID: 40022244; PMCID: PMC11869585. 13: Lu Y, Gao L, Yang Y, Shi D, Zhang Z, Wang X, Huang Y, Wu J, Meng J, Li H, Yan D. Protective role of mitophagy on microglia-mediated neuroinflammatory injury through mtDNA-STING signaling in manganese-induced parkinsonism. J Neuroinflammation. 2025 Feb 28;22(1):55. doi: 10.1186/s12974-025-03396-5. PMID: 40022162; PMCID: PMC11869743. 14: Zhou F, Feng X, Xu Z, Yan F, Song G, Tang L. Design, synthesis and biological activity of 8-hydroxy modified urolithin A derivatives as phosphodiesterase type II (PDE2) inhibitors. Bioorg Med Chem. 2025 Apr 15;121:118127. doi: 10.1016/j.bmc.2025.118127. Epub 2025 Feb 21. PMID: 40015121. 15: Kirk D, Louca P, Attaye I, Zhang X, Wong KE, Michelotti GA, Falchi M, Valdes AM, Williams FMK, Menni C. Multifluid Metabolomics Identifies Novel Biomarkers for Irritable Bowel Syndrome. Metabolites. 2025 Feb 12;15(2):121. doi: 10.3390/metabo15020121. PMID: 39997746; PMCID: PMC11857683. 16: Moussa MR, Fan N, Birk J, Provatas AA, Mehta P, Hatano Y, Chun OK, Darooghegi Mofrad M, Lotfi A, Aksenov A, Motta VN, Zenali M, Vaziri H, Grady JJ, Nakanishi M, Rosenberg DW. Systemic Inflammation and the Inflammatory Context of the Colonic Microenvironment Are Improved by Urolithin A. Cancer Prev Res (Phila). 2025 Apr 1;18(4):235-250. doi: 10.1158/1940-6207.CAPR-24-0383. PMID: 39995164. 17: Milanović Ž. Urolithin D: A promising metabolite of ellagitannin in combatting oxidative stress. Chem Biol Interact. 2025 Apr 25;411:111444. doi: 10.1016/j.cbi.2025.111444. Epub 2025 Feb 21. PMID: 39987983. 18: Huang Z, Chen G, Ren Z, Xiao L, Chen Z, Xie Y, Wang G, Zhou B. Urolithin A ameliorates schizophrenia-like behaviors and cognitive impairments in female rats by modulating NLRP3 signaling. Int Immunopharmacol. 2025 Apr 4;151:114336. doi: 10.1016/j.intimp.2025.114336. Epub 2025 Feb 22. PMID: 39987632. 19: Fluder NW, Humbel M, Recazens E, Jourdain AA, Ribi C, Tsokos GC, Comte D. Mitochondrial dysfunction drives natural killer cell dysfunction in systemic lupus erythematosus. medRxiv [Preprint]. 2025 Mar 26:2025.01.28.25321013. doi: 10.1101/2025.01.28.25321013. PMID: 39973995; PMCID: PMC11838952. 20: Wang W, Wang H, Wang L, Zhang Y, Liu H, Ci B. Urolithin B Promotes Meniscal Regeneration and Prevents the Development of Osteoarthritis in Mice. Discov Med. 2025 Feb;37(193):286-298. doi: 10.24976/Discov.Med.202537193.23. PMID: 39973552.

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