Resistomycin | CAS# 20004-62-0 | Antibiotic

MedKoo Cat#: 571100 | Name: Resistomycin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Resistomycin is an antibiotic from Streptomyces resistomycificus, also known as the trademark for kanamycin A sulfate. It is being assessed as an anticancer compound. It has also been tested for use as a therapeutic agent against tuberculosis.

Chemical Structure

Resistomycin

CAS#20004-62-0

Theoretical Analysis

MedKoo Cat#: 571100

Name: Resistomycin

CAS#: 20004-62-0

Chemical Formula: C22H16O6

Exact Mass: 376.0947

Molecular Weight: 376.36

Elemental Analysis: C, 70.21; H, 4.29; O, 25.51

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 450.00	2 Weeks
5mg	USD 1,050.00	2 Weeks

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Related CAS #

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Synonym

Resistomycin; Croceomycin; Geliomycin; Itamycin; A 3733A; A-3733A; A3733A; Antibiotic 3733A; Heliomycin

IUPAC/Chemical Name

2H-Benzo(cd)pyrene-2,6(1H)-dione, 3,5,7,10-tetrahydroxy-1,1,9-trimethyl-

InChi Key

ABLACSIRCKEUOB-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H16O6/c1-7-4-9(23)15-18-13(7)10(24)5-8-14(18)19-16(20(15)27)11(25)6-12(26)17(19)21(28)22(8,2)3/h4-6,23-26H,1-3H3

SMILES Code

O=C(C1=C(O)C=C(O)C2=C1C3=C45)C(C)(C)C3=CC(O)=C5C(C)=CC(O)=C4C2=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 376.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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PMID: 38132944; PMCID: PMC10745072. 4: Aloufi AS, Habotta OA, Abdelfattah MS, Habib MN, Omran MM, Ali SA, Abdel Moneim AE, Korany SM, Alrajhi AM. Resistomycin Suppresses Prostate Cancer Cell Growth by Instigating Oxidative Stress, Mitochondrial Apoptosis, and Cell Cycle Arrest. Molecules. 2023 Nov 30;28(23):7871. doi: 10.3390/molecules28237871. PMID: 38067602; PMCID: PMC10708360. 5: Lin MH, Islam A, Liu YH, Weng CW, Zhan JH, Liang RH, Tikhomirov AS, Shchekotikhin AE, Chueh PJ. Antibiotic heliomycin and its water-soluble 4-aminomethylated derivative provoke cell death in T24 bladder cancer cells by targeting sirtuin 1 (SIRT1). Am J Cancer Res. 2022 Mar 15;12(3):1042-1055. PMID: 35411221; PMCID: PMC8984893. 6: Kim MC, Li Z, Cullum R, Molinski TF, Eid MAG, Hebishy AMS, Faraag AHI, Abdel Moneim AE, Abdelfattah MS, Fenical W. Chlororesistoflavins A and B, Chlorinated Benzopyrene Antibiotics Produced by the Marine-Derived Actinomycete Streptomyces sp. Strain EG32. 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