MedKoo Cat#: 571072 | Name: Trimetozine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trimetozine is a sedative and hypnotic that produces a decline in the frequency of the dominant peak of EEG power spectra. The decreased frequency may be due to an anxiolytic effect.

Chemical Structure

Trimetozine
Trimetozine
CAS#635-41-6

Theoretical Analysis

MedKoo Cat#: 571072

Name: Trimetozine

CAS#: 635-41-6

Chemical Formula: C14H19NO5

Exact Mass: 281.1263

Molecular Weight: 281.31

Elemental Analysis: C, 59.78; H, 6.81; N, 4.98; O, 28.44

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 2 Weeks
200mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
Trimetozine; Opalene; Trioxyfar; Trioxazin; Sedoxazine; NSC-62939; NSC62939; NSC 62939
IUPAC/Chemical Name
4-(3,4,5-Trimethoxybenzoyl)morpholine
InChi Key
XWVOEFLBOSSYGM-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H19NO5/c1-17-11-8-10(9-12(18-2)13(11)19-3)14(16)15-4-6-20-7-5-15/h8-9H,4-7H2,1-3H3
SMILES Code
O=C(N1CCOCC1)C2=CC(OC)=C(OC)C(OC)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 281.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kawahara K, Ofuji T. Simultaneous determination of glucuronides of trimetozine in human urine by gas chromatography. J Chromatogr. 1982 Sep 10;231(2):333-9. PubMed PMID: 7130313. 2: Gomita Y, Kawasaki H, Fukamachi K, Takasaki K, Urabe M, Yamamoto R, Nakayama K, Kawai Y. [Behavioral and neuropharmacological studies of trioxazin (trimetozine) (author's transl)]. Igaku Kenkyu. 1978 Aug;48(6):469-87. Japanese. PubMed PMID: 34972. 3: Mauferon JB, Traynard J, Achaintre A. [Trimetozine in hospital geriatrics]. J Med Lyon. 1967 Mar 5;48(116):343-9. French. PubMed PMID: 5614940. 4: Krapivin SV, Khafiz'ianova RKh. [Effects of tranquilizing agents on bioelectrical activity of the rat brain]. Biull Eksp Biol Med. 1992 Jun;113(6):567-70. Russian. PubMed PMID: 1359909. 5: Morozov IS, Voronina TA. [Determination of the corrective properties of midantan in disorders of rat operant activity caused by different classes of tranquilizing agent]. Farmakol Toksikol. 1981 Sep-Oct;44(5):543-6. Russian. PubMed PMID: 6118289. 6: Voronina TA, Garibova TL. [Experimental study of the "'rebound syndrome" following discontinuation of prolonged phenazepam administration and possibilities for preventing it]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1981;81(7):1056-9. Russian. PubMed PMID: 7197446. 7: FRANK K. [Use of trioxazine in various pediatric conditions]. Gyermekgyogyaszat. 1962 May;13:151-5. Hungarian. PubMed PMID: 13894627. 8: IAKOVLEVA EK, BOBROVSKAIA MN, KRESLING EM, MIAGER VK. [Experience with Trioxazine therapy of clinical neuroses]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1962;62:1225-7. Russian. PubMed PMID: 13956058. 9: Sitarek K, Barański B, Stetkiewicz J, Stetkiewicz I. Teratogenicity, fetal and placental toxicity of 1,3,5-trioxane administered to pregnant female rats. Pol J Occup Med. 1988;1(1):51-61. PubMed PMID: 2980151. 10: SIMONYI I, BOEJTHE L, SZABO D. [ANALYTIC STUDY OF TRIOXAZINE]. Acta Pharm Hung. 1965 Jul;35:163-8. Hungarian. PubMed PMID: 14337003. 11: BOISSIER JR, SIMON P, FICHELLE-PAGNY J. [PSYCHOLEPTIC ACTION OF 4-(3,4,5-TRIMETHOXYBENZOYL)-MORPHOLINE (TRIOXAZINE)]. Therapie. 1965 Mar-Apr;20:401-8. French. PubMed PMID: 14326887. 12: SERCL M, KOVARIK J, JAROS O, VRCHA L, SIMKOVA D. [CLINICAL TRIALS WITH N-(3,4,5-TRIMETHOXYBENZOYL)-TETRAHYDRO-1,4-OXAZINE (TRIOXAZINE, V-7) BUDAPEST]. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1963;6:345-50. Czech. PubMed PMID: 14103798. 13: KOMLOS E, PETOCZ LE. Synergism of Gastropine (N-p-phenyl benzyl atropinium bromide) and Trioxazine [N-(3,4,5-trimethoxybenzoyl)-tetrahydro-1,4-oxazine]. Acta Physiol Acad Sci Hung. 1961;19:179-87. PubMed PMID: 13831026. 14: MAGYAR I. The effect of trioxazine on the electroencephalogram and the clinical picture. Ther Hung. 1960;8(3-4):9-13. PubMed PMID: 14468408. 15: BOSZORMENYI Z. Clinical observations concerning the effect of trioxazine, a tranquillizer. Ther Hung. 1960;8(3-4):13-8. PubMed PMID: 13871648.