HLI98D is a HDM2 ubiquitin ligase inhibitor. HLI98D exhibits cytotoxic activities and HDM2 E3 ligase inhibitory activities. In cells, HLI98D allows the stabilization of p53 and HDM2 and activation of p53-dependent transcription and apoptosis. The p53 tumor suppressor protein is regulated by its interaction with HDM2, which serves as a ubiquitin ligase (E3) to target p53 for degradation. HLI98D may demonstrate anti-tumor activity by inhibiting recognition of the E3 enzyme and substrate but is less potent than HLI98C.
MedKoo Cat#: 571064
Name: HLI98D
CAS#: NONE
Chemical Formula: C17H9ClN4O4
Exact Mass: 368.0312
Molecular Weight: 368.73
Elemental Analysis: C, 55.38; H, 2.46; Cl, 9.61; N, 15.19; O, 17.36
The following data is based on the product molecular weight 368.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
