MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 571059 | Name: AB-002

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AB-002 is a homologue of AB-001, which is a cannibimimetic. It is a CB (cannabinoid) receptor ligand that governs the cannabimimetic potency. It is derived from adamantane and is less potent than other ligands which can induce significant hypothermic and bradycardic effects. Its role in binding CB receptors may be useful in therapeutic discovery for relief against MS, particularly when studying selective CB2 agonists.

Chemical Structure

AB-002
AB-002
CAS#1430634-79-9

Theoretical Analysis

MedKoo Cat#: 571059

Name: AB-002

CAS#: 1430634-79-9

Chemical Formula: C25H33NO

Exact Mass: 363.2562

Molecular Weight: 363.55

Elemental Analysis: C, 82.60; H, 9.15; N, 3.85; O, 4.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
1430634-79-9 (AB-001) 1345973-49-0 (AB-002)
Synonym
AB-002; AB 002; AB002
IUPAC/Chemical Name
2-(adamantan-1-yl)-1-(1-pentyl-1H-indol-3-yl)ethan-1-one
InChi Key
BRHHDIPEHOKFET-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H33NO/c1-2-3-6-9-26-17-22(21-7-4-5-8-23(21)26)24(27)16-25-13-18-10-19(14-25)12-20(11-18)15-25/h4-5,7-8,17-20H,2-3,6,9-16H2,1H3
SMILES Code
O=C(CC12CC3CC(C2)CC(C3)C1)C4=CN(CCCCC)C5=C4C=CC=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
The endocannabinoid system consists of at least two cannabinoid (CB) receptors, namely, the CB1 and CB2 receptors. Stimulation of the CB1 receptor leads to modulation of feeding behavior, through a proposed mechanism of N-type and P/Q-type calcium channel blockade while activating the inwardly rectifying potassium channels, implicating an important role for CB1 receptor in obesity and metabolic disorders through release of neuromodulators. However, the usage of the drugs may have severe side effects on the CNS such as depression, anxiety, and suicidal thoughts. Selective CB2 agonists represent an attractive therapeutic strategy for the treatment of a variety of diseases such as MS without psychiatric side effects mediated by the CB1 receptor.

Preparing Stock Solutions

The following data is based on the product molecular weight 363.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Banister SD, Wilkinson SM, Longworth M, Stuart J, Apetz N, English K, Brooker L, Goebel C, Hibbs DE, Glass M, Connor M, McGregor IS, Kassiou M. The synthesis and pharmacological evaluation of adamantane-derived indoles: cannabimimetic drugs of abuse. ACS Chem Neurosci. 2013 Jul 17;4(7):1081-92. doi: 10.1021/cn400035r. Epub 2013 Apr 17. PubMed PMID: 23551277; PubMed Central PMCID: PMC3715837. 1: Shi Y, Duan YH, Ji YY, Wang ZL, Wu YR, Gunosewoyo H, Xie XY, Chen JZ, Yang F, Li J, Tang J, Xie X, Yu LF. Amidoalkylindoles as Potent and Selective Cannabinoid Type 2 Receptor Agonists with in Vivo Efficacy in a Mouse Model of Multiple Sclerosis. J Med Chem. 2017 Aug 3. doi: 10.1021/acs.jmedchem.7b00724. [Epub ahead of print] PubMed PMID: 28726401.