CRA-19156 is a potent HDAC8 inhibitor. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from lysines near the N termini of histones. This reaction promotes the condensation of chromatin, leading to repression of transcription. HDAC deregulation has been linked to several types of cancer, suggesting a potential use for HDAC inhibitors in oncology.
MedKoo Cat#: 561258
Name: CRA-19156
CAS#: 579511-43-6
Chemical Formula: C24H23N3O4
Exact Mass: 417.1689
Molecular Weight: 417.47
Elemental Analysis: C, 69.05; H, 5.55; N, 10.07; O, 15.33
The following data is based on the product molecular weight 417.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
