Synonym
JG-48; JG48; JG 48
IUPAC/Chemical Name
(2Z,5E)-3-Ethyl-5-[3-methyl-6-(trifluoromethyl)-2(3H)-benzothiazolylidene]-2-(2-pyridinylmethylene)-4-thiazolidinone
InChi Key
AWHRSRSTZWQWDX-PZCBVGOASA-N
InChi Code
InChI=1S/C20H16F3N3OS2/c1-3-26-16(11-13-6-4-5-9-24-13)29-17(18(26)27)19-25(2)14-8-7-12(20(21,22)23)10-15(14)28-19/h4-11H,3H2,1-2H3/b16-11-,19-17+
SMILES Code
O=C1N(CC)/C(S/C1=C2SC3=CC(C(F)(F)F)=CC=C3N/2C)=C/C4=NC=CC=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
435.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol Psychiatry. 2013 Sep 1;74(5):367-74. doi: 10.1016/j.biopsych.2013.02.027. Epub 2013 Apr 19. PubMed PMID: 23607970; PubMed Central PMCID: PMC3740016.
