Synonym
A 1110U, A-1110U, A1110U
IUPAC/Chemical Name
Carbonathioic dihydrazide, 2-((dimethylamino)thioxomethyl)-2'-(1-(2-pyridinyl)ethylidene)-
InChi Key
RPMMBVWROKDIKM-MDWZMJQESA-N
InChi Code
InChI=1S/C11H16N6S2/c1-8(9-6-4-5-7-12-9)13-14-10(18)15-16-11(19)17(2)3/h4-7H,1-3H3,(H,16,19)(H2,14,15,18)/b13-8+
SMILES Code
S=C(N/N=C(C1=NC=CC=C1)\C)NNC(N(C)C)=S
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
296.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Porter DJ, Harrington JA, Spector T. Herpes simplex virus type 1
ribonucleotide reductase: selective and synergistic inactivation by A1110U and
its iron complex. Biochem Pharmacol. 1990 Feb 15;39(4):639-46. PubMed PMID:
2154988.
2: Ellis MN, Lobe DC, Spector T. Synergistic therapy by acyclovir and A1110U for
mice orofacially infected with herpes simplex viruses. Antimicrob Agents
Chemother. 1989 Oct;33(10):1691-6. PubMed PMID: 2556074; PubMed Central PMCID:
PMC172739.
3: Spector T, Harrington JA, Porter DJ. Herpes and human ribonucleotide
reductases. Inhibition by 2-acetylpyridine
5-[(2-chloroanilino)-thiocarbonyl]-thiocarbonohydrazone (348U87). Biochem
Pharmacol. 1991 Jun 21;42(1):91-6. PubMed PMID: 1648925.
4: Spector T, Harrington JA, Morrison RW Jr, Lambe CU, Nelson DJ, Averett DR,
Biron K, Furman PA. 2-Acetylpyridine
5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent
inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster
viruses and a potentiator of acyclovir. Proc Natl Acad Sci U S A. 1989
Feb;86(3):1051-5. PubMed PMID: 2536930; PubMed Central PMCID: PMC286619.
5: Lobe DC, Spector T, Ellis MN. Synergistic topical therapy by acyclovir and
A1110U for herpes simplex virus induced zosteriform rash in mice. Antiviral Res.
1991 Feb;15(2):87-100. PubMed PMID: 1650166.
6: Spector T, Lobe DC, Ellis MN, Blumenkopf TA, Szczech GM. Inactivators of
herpes simplex virus ribonucleotide reductase: hematological profiles and in vivo
potentiation of the antiviral activity of acyclovir. Antimicrob Agents Chemother.
1992 May;36(5):934-7. PubMed PMID: 1324641; PubMed Central PMCID: PMC188768.
