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MedKoo Cat#: 561217 | Name: SR-0987
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SR-0987 is a T cell-specific RORγ (RORγt) agonist. SR-0987 induces IL-17 expression and decreases PD-1 expression in T cells in vitro.

Chemical Structure

SR-0987
CAS#303126-97-8

Theoretical Analysis

MedKoo Cat#: 561217

Name: SR-0987

CAS#: 303126-97-8

Chemical Formula: C16H10ClF6NO2

Exact Mass: 397.0304

Molecular Weight: 397.70

Elemental Analysis: C, 48.32; H, 2.53; Cl, 8.91; F, 28.66; N, 3.52; O, 8.05

Price and Availability

Size Price Availability Quantity
100mg USD 850.00 2 Weeks
200mg USD 1,450.00 2 Weeks
500mg USD 1,950.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,450.00 2 Weeks
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Related CAS #
No Data
Synonym
SR-0987; SR0987; SR 0987
IUPAC/Chemical Name
2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide
InChi Key
IZVBONMVWLTLNT-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H10ClF6NO2/c17-12-4-2-1-3-11(12)13(25)24-10-7-5-9(6-8-10)14(26,15(18,19)20)16(21,22)23/h1-8,26H,(H,24,25)
SMILES Code
O=C(NC1=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C1)C2=CC=CC=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SR-0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM.
In vitro activity:
To be determined
In vivo activity:
To be determined
Solvent mg/mL mM comments
Solubility
DMF 20.0 50.29
DMSO 15.0 37.72
Ethanol 30.0 75.43
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 397.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
To be determined
In vitro protocol:
To be determined
In vivo protocol:
To be determined
1: Chang MR, Dharmarajan V, Doebelin C, Garcia-Ordonez RD, Novick SJ, Kuruvilla DS, Kamenecka TM, Griffin PR. Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15;11(4):1012-8. doi: 10.1021/acschembio.5b00899. Epub 2016 Jan 25. PubMed PMID: 26785144; PubMed Central PMCID: PMC5178133.

View History

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