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MedKoo Cat#: 561216 | Name: CHIC-35

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CHIC-35 is a selective inhibitor of the deacetylase SIRT1.

Chemical Structure

CHIC-35
CHIC-35
CAS#848193-72-6

Theoretical Analysis

MedKoo Cat#: 561216

Name: CHIC-35

CAS#: 848193-72-6

Chemical Formula: C14H15ClN2O

Exact Mass: 262.0873

Molecular Weight: 262.74

Elemental Analysis: C, 64.00; H, 5.75; Cl, 13.49; N, 10.66; O, 6.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CHIC-35; CHIC35; CHIC 35
IUPAC/Chemical Name
(S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxamide
InChi Key
ABIVOOWWGYJNLV-JTQLQIEISA-N
InChi Code
InChI=1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
SMILES Code
O=C([C@H]1CCCCC2=C1NC3=C2C=C(Cl)C=C3)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 262.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lugrin J, Ciarlo E, Santos A, Grandmaison G, dos Santos I, Le Roy D, Roger T. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta. 2013 Jun;1833(6):1498-510. doi: 10.1016/j.bbamcr.2013.03.004. Epub 2013 Mar 13. PubMed PMID: 23499872. 2: Reverchon M, Rame C, Bunel A, Chen W, Froment P, Dupont J. VISFATIN (NAMPT) Improves In Vitro IGF1-Induced Steroidogenesis and IGF1 Receptor Signaling Through SIRT1 in Bovine Granulosa Cells. Biol Reprod. 2016 Mar;94(3):54. doi: 10.1095/biolreprod.115.134650. Epub 2016 Jan 20. PubMed PMID: 26792944.