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MedKoo Cat#: 561206 | Name: Inz-1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Inz-1 is a fungal-selective inhibitor of mitochondrial cytochrome bc1.

Chemical Structure

Inz-1
Inz-1
CAS#897776-15-7

Theoretical Analysis

MedKoo Cat#: 561206

Name: Inz-1

CAS#: 897776-15-7

Chemical Formula: C16H14N2O2

Exact Mass: 266.1055

Molecular Weight: 266.30

Elemental Analysis: C, 72.17; H, 5.30; N, 10.52; O, 12.02

Price and Availability

Size Price Availability Quantity
25mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
Inz-1; Inz1; Inz 1
IUPAC/Chemical Name
3-Phenyl-1H-indazole-1-acetic acid methyl ester
InChi Key
RBYOCUDWQCQSAM-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H14N2O2/c1-20-15(19)11-18-14-10-6-5-9-13(14)16(17-18)12-7-3-2-4-8-12/h2-10H,11H2,1H3
SMILES Code
O=C(OC)CN1N=C(C2=CC=CC=C2)C3=C1C=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 266.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Benjamin M. Vincent, Jean-Baptiste Langlois, Raja Srinivas, Alex K. Lancaster, Ruth Scherz-Shouval, Luke Whitesell, Bruce Tidor, Stephen L. Buchwald, Susan Lindquist. A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. Cell Chemical Biology, Volume 23.