MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 540244 | Name: Kaempferol
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kaempferol is found in various plant sources. It exhibits several biological activities, including inhibiting LPS-stimulated pro-inflammatory cytokine release, inducing apoptosis in bladder cancer cells, suppressing VEGF secretion and angiogenesis, and decreasing adipogenesis and triglyceride synthesis.

Chemical Structure

Kaempferol
Kaempferol
CAS#520-18-3

Theoretical Analysis

MedKoo Cat#: 540244

Name: Kaempferol

CAS#: 520-18-3

Chemical Formula: C15H10O6

Exact Mass: 286.0477

Molecular Weight: 286.24

Elemental Analysis: C, 62.94; H, 3.52; O, 33.54

Price and Availability

Size Price Availability Quantity
200mg USD 350.00 2 Weeks
500mg USD 750.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
3,4',5,7-Tetrahydroxyflavone; Campherol; Indigo Yellow; Kaempferol; Pelargidenolon;
IUPAC/Chemical Name
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
InChi Key
IYRMWMYZSQPJKC-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
SMILES Code
O=C1C(O)=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC(O)=C13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK.
In vitro activity:
To understand the mechanism behind this negative correlation, this study investigated kaempferol's ability to induce apoptosis in A2780/CP70, A2780/wt, and OVCAR-3 ovarian cancer cell lines. Kaempferol inhibited cell proliferation but did not cause necrosis in all 3 cell lines. For the apoptosis, caspase 3/7 levels were induced in a concentration-dependent manner by kaempferol treatment, with A2780/wt cells being the most responsive. Reference: Food Chem. 2011 Sep 15;128(2):513-519. https://pubmed.ncbi.nlm.nih.gov/21625365/
In vivo activity:
In Langendorff heart from Ang II infused mice, kaempferol preserved normal impulse formation at right atrium. These data suggested that kaempferol protects sinus node via inhibition of CaMKII oxidization and may be useful for preventing SND in high risk patients. Reference: Anat Cell Biol. 2015 Dec;48(4):235-43. https://pubmed.ncbi.nlm.nih.gov/26770873/
Solvent mg/mL mM
Solubility
DMF 2.0 6.99
DMSO 24.4 85.26
Ethanol 22.2 77.58
Ethanol:PBS (pH 7.2) (1:4) 0.2 0.70
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 286.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Luo H, Rankin GO, Li Z, Depriest L, Chen YC. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem. 2011 Sep 15;128(2):513-519. doi: 10.1016/j.foodchem.2011.03.073. PMID: 21625365; PMCID: PMC3102233. 2. Kang GY, Lee ER, Kim JH, Jung JW, Lim J, Kim SK, Cho SG, Kim KP. Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur J Pharmacol. 2009 Jun 2;611(1-3):17-21. doi: 10.1016/j.ejphar.2009.03.068. Epub 2009 Apr 5. PMID: 19356725. 3. An M, Kim M. Protective effects of kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization. Anat Cell Biol. 2015 Dec;48(4):235-43. doi: 10.5115/acb.2015.48.4.235. Epub 2015 Dec 21. PMID: 26770873; PMCID: PMC4701696. 4. Shin D, Park SH, Choi YJ, Kim YH, Antika LD, Habibah NU, Kang MK, Kang YH. Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma. Int J Mol Sci. 2015 Dec 16;16(12):29980-95. doi: 10.3390/ijms161226218. PMID: 26694364; PMCID: PMC4691161.
In vitro protocol:
1. Luo H, Rankin GO, Li Z, Depriest L, Chen YC. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem. 2011 Sep 15;128(2):513-519. doi: 10.1016/j.foodchem.2011.03.073. PMID: 21625365; PMCID: PMC3102233. 2. Kang GY, Lee ER, Kim JH, Jung JW, Lim J, Kim SK, Cho SG, Kim KP. Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur J Pharmacol. 2009 Jun 2;611(1-3):17-21. doi: 10.1016/j.ejphar.2009.03.068. Epub 2009 Apr 5. PMID: 19356725.
In vivo protocol:
1. An M, Kim M. Protective effects of kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization. Anat Cell Biol. 2015 Dec;48(4):235-43. doi: 10.5115/acb.2015.48.4.235. Epub 2015 Dec 21. PMID: 26770873; PMCID: PMC4701696. 2. Shin D, Park SH, Choi YJ, Kim YH, Antika LD, Habibah NU, Kang MK, Kang YH. Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma. Int J Mol Sci. 2015 Dec 16;16(12):29980-95. doi: 10.3390/ijms161226218. PMID: 26694364; PMCID: PMC4691161.