CPUY192018 Disodium is a potent small-molecule inhibitor of the Keap1-Nrf2 PPI. CPUY192018 Disodium has a cytoprotective effect against DSS in both NCM460 cells and mouse colon via the activation of Nrf2 signaling. Activation of Nrf2 by directly inhibiting the Keap1-Nrf2 PPI may be beneficial as a treatment for ulcerative colitis.
MedKoo Cat#: 561176
Name: CPUY192018 Disodium
CAS#: 1567836-15-0 (free acid)
Chemical Formula: C28H24N2Na2O10S2
Exact Mass:
Molecular Weight: 658.60
Elemental Analysis: C, 51.06; H, 3.67; N, 4.25; Na, 6.98; O, 24.29; S, 9.74
The following data is based on the product molecular weight 658.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
