MDK-3298 | Mcl-1 Inhibitor-5 | CAS#2012563-29-8 | Mcl-1 inhibitor

MedKoo Cat#: 561170 | Name: MDK-3298

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDK-3298, also know nas Mcl-1 Inhibitor-5, is a reversible covalent inhibitor for Mcl-1, a protein-protein interaction (PPI) target. MDK-3298 has CAS#2012563-29-8. the last 4 digit of its CAS# is used in name.

Chemical Structure

MDK-3298

CAS#2012563-29-8

Theoretical Analysis

MedKoo Cat#: 561170

Name: MDK-3298

CAS#: 2012563-29-8

Chemical Formula: C35H32BN3O7

Exact Mass: 617.2333

Molecular Weight: 617.47

Elemental Analysis: C, 68.08; H, 5.22; B, 1.75; N, 6.81; O, 18.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

MDK-3298; MDK 3298; MDK3298; Mcl-1 Inhibitor-5; Mcl-1 Inhibitor 5; Mcl-1 Inhibitor5

IUPAC/Chemical Name

7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimethyl-1Hpyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid

InChi Key

RMIRRIJMEIKMFL-UHFFFAOYSA-N

InChi Code

InChI=1S/C35H32BN3O7/c1-21-32(30(38-39(21)2)20-46-24-15-16-29(36(43)44)23(18-24)19-40)28-12-6-11-26-27(34(35(41)42)37-33(26)28)13-7-17-45-31-14-5-9-22-8-3-4-10-25(22)31/h3-6,8-12,14-16,18-19,37,43-44H,7,13,17,20H2,1-2H3,(H,41,42)

SMILES Code

O=C(C(N1)=C(CCCOC2=C3C=CC=CC3=CC=C2)C4=C1C(C5=C(C)N(C)N=C5COC6=CC=C(B(O)O)C(C=O)=C6)=CC=C4)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 617.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Akçay G, Belmonte MA, Aquila B, Chuaqui C, Hird AW, Lamb ML, Rawlins PB, Su N, Tentarelli S, Grimster NP, Su Q. Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain. Nat Chem Biol. 2016 Nov;12(11):931-936. doi: 10.1038/nchembio.2174. Epub 2016 Sep 5. PubMed PMID: 27595327.