MDK-3345 | Mcl-1 Inhibitor-11 | CAS# 2012563-34-5 | Mcl-1 inhibitor

MedKoo Cat#: 561169 | Name: MDK-3345

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDK-3345, also known as Mcl-1 Inhibitor-11, is a reversible covalent inhibitor for Mcl-1. MDK-3345 has improved water solubility from Mcl-1 Inhibitor-5. MDK-3345 has CAS#2012563-34-5. The last 4 digit of its CAS# is used in its name.

Chemical Structure

MDK-3345

CAS# 2012563-34-5

Theoretical Analysis

MedKoo Cat#: 561169

Name: MDK-3345

CAS#: 2012563-34-5

Chemical Formula: C36H34BN3O7

Exact Mass: 631.2490

Molecular Weight: 631.49

Elemental Analysis: C, 68.47; H, 5.43; B, 1.71; N, 6.65; O, 17.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

MDK-3345; MDK 3345; MDK3345; Mcl-1 Inhibitor-11; Mcl-1 Inhibitor 11; Mcl-1 Inhibitor11

IUPAC/Chemical Name

7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimethyl-1Hpyrazol-4-yl)-1-methyl-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid

InChi Key

MUZZYPOVNNFUHN-UHFFFAOYSA-N

InChi Code

InChI=1S/C36H34BN3O7/c1-22-33(31(38-40(22)3)21-47-25-16-17-30(37(44)45)24(19-25)20-41)29-13-7-12-27-28(35(36(42)43)39(2)34(27)29)14-8-18-46-32-15-6-10-23-9-4-5-11-26(23)32/h4-7,9-13,15-17,19-20,44-45H,8,14,18,21H2,1-3H3,(H,42,43)

SMILES Code

O=C(C(N1C)=C(CCCOC2=C3C=CC=CC3=CC=C2)C4=C1C(C5=C(C)N(C)N=C5COC6=CC=C(B(O)O)C(C=O)=C6)=CC=C4)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 631.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Akçay G, Belmonte MA, Aquila B, Chuaqui C, Hird AW, Lamb ML, Rawlins PB, Su N, Tentarelli S, Grimster NP, Su Q. Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain. Nat Chem Biol. 2016 Nov;12(11):931-936. doi: 10.1038/nchembio.2174. Epub 2016 Sep 5. PubMed PMID: 27595327.