MedKoo Cat#: 561146 | Name: MDK-3017
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDK-3017, also known as K-Ras-IN-2 or K-Ras Inhibitor-2, is a small molecule K-Ras inhibitor. The last four digits of the compound's CAS registry number are used in its name. MDK-3017 binds to K-Ras in a hydrophobic pocket occupied by Tyr-71.

Chemical Structure

MDK-3017
MDK-3017
CAS#84783-01-7

Theoretical Analysis

MedKoo Cat#: 561146

Name: MDK-3017

CAS#: 84783-01-7

Chemical Formula: C11H13NOS

Exact Mass: 207.0718

Molecular Weight: 207.29

Elemental Analysis: C, 63.74; H, 6.32; N, 6.76; O, 7.72; S, 15.47

Price and Availability

Size Price Availability Quantity
100mg USD 550.00 2 Weeks
200mg USD 950.00 2 Weeks
500mg USD 1,950.00 2 Weeks
1g USD 2,850.00 2 Weeks
2g USD 4,650.00 2 Weeks
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Related CAS #
No Data
Synonym
MDK-3017; MDK3017; MDK 3017; K-Ras-IN-2; K-Ras Inhibitor-2
IUPAC/Chemical Name
(2-Hydroxy-phenyl)-pyrrolidin-1-yl-methanethione
InChi Key
QIKLOVZAPGSYNO-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H13NOS/c13-10-6-2-1-5-9(10)11(14)12-7-3-4-8-12/h1-2,5-6,13H,3-4,7-8H2
SMILES Code
S=C(C1=CC=CC=C1O)N2CCCC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 207.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sun Q, Burke JP, Phan J, et al. Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation. Angewandte Chemie (International ed in English). 2012;51(25):6140-6143. doi:10.1002/anie.201201358.