G-Glu-Ala | CAS#5875-41-2 | GGCT substrate

MedKoo Cat#: 561086 | Name: G-Glu-Ala

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

G-Glu-Ala, also known as gamma-Glutamylalanine, is the substrate of CRF21 (gamma-Glutamylcyclotransferase, GGCT).

Chemical Structure

G-Glu-Ala

CAS#5875-41-2

Theoretical Analysis

MedKoo Cat#: 561086

Name: G-Glu-Ala

CAS#: 5875-41-2

Chemical Formula: C8H14N2O5

Exact Mass: 218.0903

Molecular Weight: 218.21

Elemental Analysis: C, 44.03; H, 6.47; N, 12.84; O, 36.66

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 350.00	2 Weeks
500mg	USD 650.00	2 Weeks

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Related CAS #

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Synonym

G-Glu-Ala; γ-L-Glutamyl-L-alanine; gamma-Glu-Ala; H-Gamma-Glu-Ala-OH; gamma-Glutamylalanine; 5-L-Glutamyl-L-alanine; H-Glu(Ala-OH)-OH

IUPAC/Chemical Name

(2S)-2-Amino-5-[[(1S)-1-carboxyethyl]amino]-5-oxopentanoic acid

InChi Key

WQXXXVRAFAKQJM-WHFBIAKZSA-N

InChi Code

InChI=1S/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1

SMILES Code

O=C(O)[C@@H](N)CCC(N[C@H](C(O)=O)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	Water	50.0	229.14

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 218.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: York MJ, Crossley MJ, Hyslop SJ, Fisher ML, Kuchel PW. gamma-Glutamylcyclotransferase: inhibition by D-beta-aminoglutaryl-L-alanine and analysis of the solvent kinetic isotope effect. Eur J Biochem. 1989 Sep 1;184(1):97-101. PubMed PMID: 2570694. 2: Board PG, Moore KA, Smith JE. Purification and properties of gamma-glutamylcyclotransferase from human erythrocytes. Biochem J. 1978 Aug 1;173(2):427-31. PubMed PMID: 29601; PubMed Central PMCID: PMC1185795.