MedKoo Cat#: 561064 | Name: Eicosapentaenoyl Serotonin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Eicosapentaenoyl Serotonin is a dual fatty acid amide hydrolase (FAAH) and TRPV1 antagonist.

Chemical Structure

Eicosapentaenoyl Serotonin
Eicosapentaenoyl Serotonin
CAS#199875-71-3

Theoretical Analysis

MedKoo Cat#: 561064

Name: Eicosapentaenoyl Serotonin

CAS#: 199875-71-3

Chemical Formula: C30H40N2O2

Exact Mass: 460.3090

Molecular Weight: 460.66

Elemental Analysis: C, 78.22; H, 8.75; N, 6.08; O, 6.95

Price and Availability

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5mg USD 550.00 2 Weeks
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Synonym
Eicosapentaenoyl Serotonin;
IUPAC/Chemical Name
(5Z,8Z,11Z,14Z,17Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]icosa-5,8,11,14,17-pentaenamide
InChi Key
RYPAMQYLBIIZHL-JLNKQSITSA-N
InChi Code
InChI=1S/C30H40N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(34)31-23-22-26-25-32-29-21-20-27(33)24-28(26)29/h3-4,6-7,9-10,12-13,15-16,20-21,24-25,32-33H,2,5,8,11,14,17-19,22-23H2,1H3,(H,31,34)/b4-3-,7-6-,10-9-,13-12-,16-15-
SMILES Code
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(NCCC1=CNC2=C1C=C(O)C=C2)=O
Appearance
A solution in ethanol
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 460.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang Y, Balvers MGJ, Hendriks HFJ, Wilpshaar T, van Heek T, Witkamp RF, Meijerink J. Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):823-831. doi: 10.1016/j.bbalip.2017.05.008. Epub 2017 May 16. PMID: 28526351. 2: Watson JE, Kim JS, Das A. Emerging class of omega-3 fatty acid endocannabinoids & their derivatives. Prostaglandins Other Lipid Mediat. 2019 Aug;143:106337. doi: 10.1016/j.prostaglandins.2019.106337. Epub 2019 May 11. PMID: 31085370; PMCID: PMC6685292. 3: Verhoeckx KC, Voortman T, Balvers MG, Hendriks HF, M Wortelboer H, Witkamp RF. Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract. Biochim Biophys Acta. 2011 Oct;1811(10):578-86. doi: 10.1016/j.bbalip.2011.07.008. Epub 2011 Jul 21. PMID: 21798367.