SF2312 | CAS#107729-45-3 | enolase inhibitor

MedKoo Cat#: 561044 | Name: SF2312

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SF2312 is an enolase inhibitor. SF2312 is a phosphonate antibiotic of unknown mode of action produced by the actinomycete Micromonospora, which is active under anaerobic conditions.

Chemical Structure

SF2312

CAS#107729-45-3

Theoretical Analysis

MedKoo Cat#: 561044

Name: SF2312

CAS#: 107729-45-3

Chemical Formula: C4H8NO6P

Exact Mass: 197.0089

Molecular Weight: 197.08

Elemental Analysis: C, 24.38; H, 4.09; N, 7.11; O, 48.71; P, 15.72

Price and Availability

Size	Price	Availability
1mg	USD 150.00	Ready to Ship
5mg	USD 450.00	Ready to Ship
10mg	USD 750.00	Ready to Ship
25mg	USD 1,350.00	Ready to Ship
50mg	USD 2,350.00	Ready to Ship
100mg	USD 3,850.00	Ready to Ship

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Related CAS #

No Data

Synonym

SF2312; SF 2312; SF-2312;

IUPAC/Chemical Name

(1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid

InChi Key

CGWBGDOPBYWJKZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C4H8NO6P/c6-3-1-2(12(9,10)11)4(7)5(3)8/h2-3,6,8H,1H2,(H2,9,10,11)

SMILES Code

O=C1N(O)C(O)CC1P(O)(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in water

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#Y24X01M06

QC Data

View QC data: current batch, Lot#Y24X01M06

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

SF2312 is an Enolase inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively.

In vitro activity:

This study provides evidence, including a novel X-ray structure, that SF2312 is a highly potent, low-nanomolar inhibitor of enolase. It demonstrated that SF2312 is active against a range of bacteria, with strong activity against Salmonella and Staphylococcus, weak activity against E. coli, and no activity against fungi. Reference: Nat Chem Biol. 2016 Dec;12(12):1053-1058. https://pubmed.ncbi.nlm.nih.gov/27723749/

In vivo activity:

To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 197.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Krucinska J, Lombardo MN, Erlandsen H, Hazeen A, Duay SS, Pattis JG, Robinson VL, May ER, Wright DL. Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate. Sci Rep. 2019 Nov 19;9(1):17106. doi: 10.1038/s41598-019-53301-3. PMID: 31745118; PMCID: PMC6863902. 2. Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR 4th, Sun D, Prasad BAB, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol. 2016 Dec;12(12):1053-1058. doi: 10.1038/nchembio.2195. Epub 2016 Oct 10. PMID: 27723749; PMCID: PMC5110371.

In vitro protocol:

In vivo protocol:

To be determined

1: Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR 4th, Sun D, Prasad BA, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol. 2016 Dec;12(12):1053-1058. doi: 10.1038/nchembio.2195. Epub 2016 Oct 10. PubMed PMID: 27723749; PubMed Central PMCID: PMC5110371.