MDK-6983, also known as Autophagy inhibitor 6k, is a autophagy inhibitor. MDK-6983 has CAS#1227476-98-3. The last 4 digital is used in its name. MDK-6983 disrupts the dynamics of actin cytoskeleton in human melanoma cells, affecting processes essential for the maintenance and expansion of tumours such as cell adhesion, motility, proliferation, vesicular transport, and autophagic flux. Inhibition of autophagy by MDK-6983 increased the sensitivity of melanoma cells to metabolic stress induced by rotenone or nutrient starvation and potentiated the anti-proliferative activity of small molecule multikinase inhibitor sorafenib.
MedKoo Cat#: 561022
Name: MDK-6983
CAS#: 1227476-98-3
Chemical Formula: C22H18Cl2N2O3
Exact Mass: 428.0694
Molecular Weight: 429.30
Elemental Analysis: C, 61.55; H, 4.23; Cl, 16.52; N, 6.53; O, 11.18
The following data is based on the product molecular weight 429.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
