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MedKoo Cat#: 530673 | Name: SLUPP-417

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SLUPP-417 is an efflux pump inhibitor (EPI) having the potential to reinvigorate existing antibiotics that are currently ineffective due to efflux mechanisms. SLUPP-417 interact with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in Escherichia coli. SLUPP-417demonstrates favorable properties as potential EPIs in E. coli cells including the ability to penetrate the outer membrane, and potentiation of the activity of novobiocin and erythromycin.

Chemical Structure

SLUPP-417
SLUPP-417
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 530673

Name: SLUPP-417

CAS#: Unknown

Chemical Formula: C21H23N3O

Exact Mass: 333.1841

Molecular Weight: 333.44

Elemental Analysis: C, 75.65; H, 6.95; N, 12.60; O, 4.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SLUPP-417; SLUPP 417; SLUPP417;
IUPAC/Chemical Name
(E)-N-(4-(4,5-Dihydro-1H-imidazol -2-yl)phenyl)-3-(4-isopropylphenyl)acrylamide
InChi Key
CXKARUGMFISLBH-LFYBBSHMSA-N
InChi Code
InChI=1S/C21H23N3O/c1-15(2)17-6-3-16(4-7-17)5-12-20(25)24-19-10-8-18(9-11-19)21-22-13-14-23-21/h3-12,15H,13-14H2,1-2H3,(H,22,23)(H,24,25)/b12-5+
SMILES Code
O=C(NC1=CC=C(C2=NCCN2)C=C1)/C=C/C3=CC=C(C(C)C)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 333.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Haynes KM, Abdali N, Jhawar V, Zgurskaya HI, Parks JM, Green AT, Baudry JY, Rybenkov VV, Smith JC, Walker JK. Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli. J Med Chem. 2017 Jun 26. doi: 10.1021/acs.jmedchem.7b00453. [Epub ahead of print] PubMed PMID: 28650638.