Ginsenoside Rg1 | CAS#22427-39-0 | prevents platelet aggregation | fibriogen binding

MedKoo Cat#: 540171 | Name: Ginsenoside Rg1

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ginsenoside Rg1 is found in species of Panax. It exihibits several biological activities, including limiting decreases in cognitive capacity and neurogenesis, preventing platelet aggregation and fibriogen binding, inhibiting inflammation and hepatic stellate cell activation, and inducing apoptosis in leukemia cells.

Chemical Structure

Ginsenoside Rg1

CAS#22427-39-0

Theoretical Analysis

MedKoo Cat#: 540171

Name: Ginsenoside Rg1

CAS#: 22427-39-0

Chemical Formula: C42H72O14

Exact Mass: 800.4922

Molecular Weight: 801.02

Elemental Analysis: C, 62.98; H, 9.06; O, 27.96

Price and Availability

Size	Price	Availability
100mg	USD 450.00	2 Weeks
250mg	USD 850.00	2 Weeks
1g	USD 1,650.00	2 Weeks

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Synonym

Ginsenoside Rg1; Ginsenoside-Rg1; Sanchinoside C1; Sanchinoside Rg1; Panaxoside A; Ginsenoside A2; Ginsenoside g1; Panaxoside Rg1; (20S)-ginsenoside Rg1

IUPAC/Chemical Name

(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

InChi Key

YURJSTAIMNSZAE-HHNZYBFYSA-N

InChi Code

InChI=1S/C42H72O14/c1-20(2)10-9-13-42(8,56-37-34(52)32(50)30(48)25(19-44)55-37)21-11-15-40(6)28(21)22(45)16-26-39(5)14-12-27(46)38(3,4)35(39)23(17-41(26,40)7)53-36-33(51)31(49)29(47)24(18-43)54-36/h10,21-37,43-52H,9,11-19H2,1-8H3/t21-,22+,23-,24+,25+,26+,27-,28-,29+,30+,31-,32-,33+,34+,35-,36+,37-,39+,40+,41+,42-/m0/s1

SMILES Code

O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]4(C)C[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@]6([H])[C@@](CC[C@H](O)C6(C)C)(C)[C@@]4([H])C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 801.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Miao HH, Zhen Y, Ding GN, Hong FX, Xie ZC, Tian M. Ginsenoside Rg1 Attenuates Isoflurane-induced Caspase-3 Activation via Inhibiting Mitochondrial Dysfunction. Biomed Environ Sci. 2015 Feb;28(2):116-26. doi: 10.3967/bes2015.014. PubMed PMID: 25716562. 2: Zhu G, Wang Y, Li J, Wang J. Chronic treatment with ginsenoside Rg1 promotes memory and hippocampal long-term potentiation in middle-aged mice. Neuroscience. 2015 Apr 30;292:81-9. doi: 10.1016/j.neuroscience.2015.02.031. Epub 2015 Feb 25. PubMed PMID: 25724866. 3: Wang X, Wang C, Pu F, Lin P, Qian T. Metabolite profiling of ginsenoside Rg1 after oral administration in rat. Biomed Chromatogr. 2014 Oct;28(10):1320-4. doi: 10.1002/bmc.3164. Epub 2014 Feb 26. PubMed PMID: 24616108. 4: Yu HT, Zhen J, Pang B, Gu JN, Wu SS. Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats. J Zhejiang Univ Sci B. 2015 May;16(5):344-54. doi: 10.1631/jzus.B1400204. PubMed PMID: 25990051; PubMed Central PMCID: PMC4432986. 5: Yu M, Yu X, Guo D, Yu B, Li L, Liao Q, Xing R. Ginsenoside Rg1 attenuates invasion and migration by inhibiting transforming growth factor-β1-induced epithelial to mesenchymal transition in HepG2 cells. Mol Med Rep. 2015 Apr;11(4):3167-73. doi: 10.3892/mmr.2014.3098. Epub 2014 Dec 16. PubMed PMID: 25515352. 6: Lee SY, Jeong JJ, Eun SH, Kim DH. Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20(S)-protopanaxatriol in mice with TNBS-induced colitis. Eur J Pharmacol. 2015 Sep 5;762:333-43. doi: 10.1016/j.ejphar.2015.06.011. Epub 2015 Jun 6. PubMed PMID: 26054809. 7: Zhu J, Mu X, Zeng J, Xu C, Liu J, Zhang M, Li C, Chen J, Li T, Wang Y. Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. PLoS One. 2014 Jun 30;9(6):e101291. doi: 10.1371/journal.pone.0101291. eCollection 2014. PubMed PMID: 24979747; PubMed Central PMCID: PMC4076296. 8: Kwok HH, Chan LS, Poon PY, Yue PY, Wong RN. Ginsenoside-Rg1 induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a. Toxicol Appl Pharmacol. 2015 Sep 15;287(3):276-83. doi: 10.1016/j.taap.2015.06.014. Epub 2015 Jun 23. PubMed PMID: 26115870. 9: Jiang GZ, Li JC. Protective effects of ginsenoside Rg1 against colistin sulfate-induced neurotoxicity in PC12 cells. Cell Mol Neurobiol. 2014 Mar;34(2):167-72. doi: 10.1007/s10571-013-9998-4. Epub 2013 Oct 30. PubMed PMID: 24170279. 10: Li CP, Zhang MS, Liu J, Geng S, Li J, Zhu JH, Zhang YY, Jia YY, Wang L, Wang SH, Wang YP. [Research of anti-aging mechanism of ginsenoside Rg1 on brain]. Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4442-7. Chinese. PubMed PMID: 25850282. 11: Liu Z, Qi Y, Cheng Z, Zhu X, Fan C, Yu SY. The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats. Neuroscience. 2016 May 13;322:358-69. doi: 10.1016/j.neuroscience.2016.02.050. Epub 2016 Feb 27. PubMed PMID: 26926964. 12: Zhou Q, Jiang L, Xu C, Luo D, Zeng C, Liu P, Yue M, Liu Y, Hu X, Hu H. Ginsenoside Rg1 inhibits platelet activation and arterial thrombosis. Thromb Res. 2014 Jan;133(1):57-65. doi: 10.1016/j.thromres.2013.10.032. Epub 2013 Oct 25. PubMed PMID: 24196231. 13: He Q, Sun J, Wang Q, Wang W, He B. Neuroprotective effects of ginsenoside Rg1 against oxygen-glucose deprivation in cultured hippocampal neurons. J Chin Med Assoc. 2014 Mar;77(3):142-9. doi: 10.1016/j.jcma.2014.01.001. Epub 2014 Feb 16. PubMed PMID: 24548377. 14: Li YB, Wang Y, Tang JP, Chen D, Wang SL. Neuroprotective effects of ginsenoside Rg1-induced neural stem cell transplantation on hypoxic-ischemic encephalopathy. Neural Regen Res. 2015 May;10(5):753-9. doi: 10.4103/1673-5374.156971. PubMed PMID: 26109949; PubMed Central PMCID: PMC4468766. 15: Wang P, Wei X, Zhang F, Yang K, Qu C, Luo H, He L. Ginsenoside Rg1 of Panax ginseng stimulates the proliferation, odontogenic/osteogenic differentiation and gene expression profiles of human dental pulp stem cells. Phytomedicine. 2014 Jan 15;21(2):177-83. doi: 10.1016/j.phymed.2013.08.021. Epub 2013 Sep 25. PubMed PMID: 24075212. 16: Bao S, Zou Y, Wang B, Li Y, Zhu J, Luo Y, Li J. Ginsenoside Rg1 improves lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and modulating infiltration of M2 macrophages. Int Immunopharmacol. 2015 Sep;28(1):429-34. doi: 10.1016/j.intimp.2015.06.022. Epub 2015 Jun 27. PubMed PMID: 26122136. 17: Zhao BS, Liu Y, Gao XY, Zhai HQ, Guo JY, Wang XY. Effects of ginsenoside Rg1 on the expression of toll-like receptor 3, 4 and their signalling transduction factors in the NG108-15 murine neuroglial cell line. Molecules. 2014 Oct 22;19(10):16925-36. doi: 10.3390/molecules191016925. PubMed PMID: 25340298. 18: Xie CL, Wang WW, Xue XD, Zhang SF, Gan J, Liu ZG. A systematic review and meta-analysis of Ginsenoside-Rg1 (G-Rg1) in experimental ischemic stroke. Sci Rep. 2015 Jan 20;5:7790. doi: 10.1038/srep07790. PubMed PMID: 25600516; PubMed Central PMCID: PMC5379000. 19: Li D, Wang J, Hou J, Fu J, Chang D, Bensoussan A, Liu J. Ginsenoside Rg1 protects starving H9c2 cells by dissociation of Bcl-2-Beclin1 complex. BMC Complement Altern Med. 2016 May 26;16:146. doi: 10.1186/s12906-016-1112-2. PubMed PMID: 27228978; PubMed Central PMCID: PMC4881172. 20: Zhou Y, Li HQ, Lu L, Fu DL, Liu AJ, Li JH, Zheng GQ. Ginsenoside Rg1 provides neuroprotection against blood brain barrier disruption and neurological injury in a rat model of cerebral ischemia/reperfusion through downregulation of aquaporin 4 expression. Phytomedicine. 2014 Jun 15;21(7):998-1003. doi: 10.1016/j.phymed.2013.12.005. Epub 2014 Jan 22. PubMed PMID: 24462216.