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MedKoo Cat#: 530660 | Name: PF-1163B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-1163B is an antifungal agent produced by Penicillium sp. II. PF-1163B inhibits ergosterol (ERG) synthesis (IC50 = 34 ng/ml). PF-1163B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotoxic activity against mammalian cells.

Chemical Structure

PF-1163B
PF-1163B
CAS#258871-60-2

Theoretical Analysis

MedKoo Cat#: 530660

Name: PF-1163B

CAS#: 258871-60-2

Chemical Formula: C27H43NO5

Exact Mass: 461.3141

Molecular Weight: 461.64

Elemental Analysis: C, 70.25; H, 9.39; N, 3.03; O, 17.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PF-1163B; PF 1163B; PF1163B; (-)-PF1163B.
IUPAC/Chemical Name
(3S,10R,13R)-3-[[4-(2-hydroxyethoxy)phenyl]methyl]-4,10-dimethyl-13-pentyl-1-Oxa-4-azacyclotridecane-2,5-dione
InChi Key
PCRJJAXIHTZHNU-SDUSCBPUSA-N
InChi Code
InChI=1S/C27H43NO5/c1-4-5-6-10-24-15-12-21(2)9-7-8-11-26(30)28(3)25(27(31)33-24)20-22-13-16-23(17-14-22)32-19-18-29/h13-14,16-17,21,24-25,29H,4-12,15,18-20H2,1-3H3/t21-,24-,25+/m1/s1
SMILES Code
O=C([C@H](CC1=CC=C(OCCO)C=C1)N2C)O[C@H](CCCCC)CC[C@H](C)CCCCC2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 461.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bouazza F, Renoux B, Bachmann C, Gesson JP. Total synthesis and conformational analysis of the antifungal agent (-)-PF1163B. Org Lett. 2003 Oct 30;5(22):4049-52. Erratum in: Org Lett. 2004 Mar 18;6(6):1069. PubMed PMID: 14572246. 2: Sasaki T, Nose H, Hosoya A, Yoshida S, Kawaguchi M, Watanabe T, Usui T, Ohtsuka Y, Shomura T, Takano S, Tatsuta K. PF1163A and B, new antifungal antibiotics produced by Penicillium sp. II. Physico-chemical properties and structure elucidation. J Antibiot (Tokyo). 2000 Jan;53(1):38-44. PubMed PMID: 10724006. 3: Nose H, Seki A, Yaguchi T, Hosoya A, Sasaki T, Hoshiko S, Shomura T. PF1163A and B, new antifungal antibiotics produced by Penicillium sp. I. Taxonomy of producing strain, fermentation, isolation and biological activities. J Antibiot (Tokyo). 2000 Jan;53(1):33-7. PubMed PMID: 10724005. 4: Tatsuta K, Takano S, Ikeda Y, Nakano S, Miyazaki S. The total synthesis and absolute structure of antifungal antibiotics(-)-PF1163A and B. J Antibiot (Tokyo). 1999 Dec;52(12):1146-51. PubMed PMID: 10695680.